GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:17395546

From GONUTS
Jump to: navigation, search
Citation

Carmell, MA, Girard, A, van de Kant, HJ, Bourc'his, D, Bestor, TH, de Rooij, DG and Hannon, GJ (2007) MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev. Cell 12:503-14

Abstract

Small RNAs associate with Argonaute proteins and serve as sequence-specific guides for regulation of mRNA stability, productive translation, chromatin organization, and genome structure. In animals, the Argonaute superfamily segregates into two clades. The Argonaute clade acts in RNAi and in microRNA-mediated gene regulation in partnership with 21-22 nt RNAs. The Piwi clade, and their 26-30 nt piRNA partners, have yet to be assigned definitive functions. In mice, two Piwi-family members have been demonstrated to have essential roles in spermatogenesis. Here, we examine the effects of disrupting the gene encoding the third family member, MIWI2. Miwi2-deficient mice display a meiotic-progression defect in early prophase of meiosis I and a marked and progressive loss of germ cells with age. These phenotypes may be linked to an inappropriate activation of transposable elements detected in Miwi2 mutants. Our observations suggest a conserved function for Piwi-clade proteins in the control of transposons in the germline.

Links

PubMed Online version:10.1016/j.devcel.2007.03.001

Keywords

Animals; Apoptosis; Argonaute Proteins; Cell Lineage; DNA Methylation; DNA Transposable Elements; Male; Meiosis; Mice; Mice, Inbred C57BL; Mutation; Proteins/genetics; Proteins/physiology; Spermatocytes/metabolism; Spermatocytes/physiology; Spermatogenesis; Testis/abnormalities; Testis/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:PIWL4

involved_in

GO:0007283: spermatogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:PIWL4

involved_in

GO:0031047: gene silencing by RNA

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:PIWL4

involved_in

GO:0034587: piRNA metabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.