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PMID:17360684

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Citation

Kwon, JY, Dahanukar, A, Weiss, LA and Carlson, JR (2007) The molecular basis of CO2 reception in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 104:3574-8

Abstract

CO(2) elicits a response from many insects, including mosquito vectors of diseases such as malaria and yellow fever, but the molecular basis of CO(2) detection is unknown in insects or other higher eukaryotes. Here we show that Gr21a and Gr63a, members of a large family of Drosophila seven-transmembrane-domain chemoreceptor genes, are coexpressed in chemosensory neurons of both the larva and the adult. The two genes confer CO(2) response when coexpressed in an in vivo expression system, the "empty neuron system." The response is highly specific for CO(2) and dependent on CO(2) concentration. The response shows an equivalent dependence on the dose of Gr21a and Gr63a. None of 39 other chemosensory receptors confers a comparable response to CO(2). The identification of these receptors may now allow the identification of agents that block or activate them. Such agents could affect the responses of insect pests to the humans they seek.

Links

PubMed PMC1805529 Online version:10.1073/pnas.0700079104

Keywords

Animals; Carbon Dioxide/pharmacology; Carbon Dioxide/physiology; Chemoreceptor Cells/drug effects; Chemoreceptor Cells/physiology; Drosophila/metabolism; Drosophila/physiology; Drosophila Proteins/metabolism; Electrophysiology; Immunohistochemistry; Larva/metabolism; Larva/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:GR21A

involved_in

GO:0010037: response to carbon dioxide

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0035468

P

Seeded From UniProt

complete

DROME:GR21A

involved_in

GO:0003031: detection of carbon dioxide

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0041250

P

Seeded From UniProt

complete

DROME:GR63A

involved_in

GO:0010037: response to carbon dioxide

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0041250

P

Seeded From UniProt

complete

DROME:GR63A

involved_in

GO:0003031: detection of carbon dioxide

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0041250

P

Seeded From UniProt

complete


See also

References

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