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PMID:17359964

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Citation

Davis, SW and Camper, SA (2007) Noggin regulates Bmp4 activity during pituitary induction. Dev. Biol. 305:145-60

Abstract

Bone morphogenetic protein (Bmp) signaling is critical for the development and patterning of the mouse pituitary from the initial induction of Rathke's pouch to cell specification in the anterior lobe. We examined the regulation of Bmp signaling during pituitary development by analyzing null embryos for noggin, a Bmp 2 and 4 antagonist. Noggin is expressed in the ventral diencephalon during Rathke's pouch induction, in the underlying cartilage plate during cell specification and in the adult anterior pituitary gland. Noggin null embryos have a variable pituitary phenotype, which ranges from a rostrally displaced Rathke's pouch to induction of secondary pituitary tissue. While cell specification in the anterior pituitary appears normal, patterning in the ventral diencephalon is disrupted; Bmp4 activity is expanded resulting in Fibroblast growth factor 10 repression and in a rostral shift in the boundary between the Bmp4 and Sonic hedgehog expression domains. The expanded domain of Bmp4 activity also results in additional invaginations of oral ectoderm and can shift the position of Rathke's pouch or create secondary pituitary tissue. This work demonstrates the importance of attenuating the activity of Bmp signaling during pituitary induction in order to maintain the proper balance of signaling factors necessary for pituitary organogenesis.

Links

PubMed PMC1913218 Online version:10.1016/j.ydbio.2007.02.001

Keywords

Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins/metabolism; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Differentiation/physiology; Cell Proliferation; Embryonic Induction/physiology; Gene Expression Regulation, Developmental/physiology; Immunohistochemistry; Mice; Mice, Knockout; Pituitary Gland/embryology; Pituitary Gland/metabolism; Signal Transduction/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:BMR1A

acts_upstream_of_or_within

GO:0021983: pituitary gland development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158342
MGI:MGI:2158390

P

Seeded From UniProt

complete

MOUSE:BMR1A

acts_upstream_of_or_within

GO:0001701: in utero embryonic development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158342
MGI:MGI:2158390

P

Seeded From UniProt

complete

MOUSE:BMR1A

acts_upstream_of_or_within

GO:0007399: nervous system development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158342
MGI:MGI:2158390

P

Seeded From UniProt

complete

MOUSE:BMR1A

acts_upstream_of_or_within

GO:0003007: heart morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158342
MGI:MGI:2158390

P

Seeded From UniProt

complete

MOUSE:BMR1A

acts_upstream_of_or_within

GO:0048589: developmental growth

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158342
MGI:MGI:2158390

P

Seeded From UniProt

complete

MOUSE:BMR1A

acts_upstream_of_or_within

GO:0048568: embryonic organ development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158342
MGI:MGI:2158390

P

Seeded From UniProt

complete

MOUSE:NOGG

acts_upstream_of_or_within

GO:0030510: regulation of BMP signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1862000

P

Seeded From UniProt

complete

MOUSE:NOGG

acts_upstream_of_or_within

GO:0021983: pituitary gland development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1862000

P

Seeded From UniProt

complete

MOUSE:NOGG

acts_upstream_of_or_within

GO:0001701: in utero embryonic development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1862000

P

Seeded From UniProt

complete


See also

References

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