GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:17283102
| Citation |
Matsumoto, Y, Kaito, C, Morishita, D, Kurokawa, K and Sekimizu, K (2007) Regulation of exoprotein gene expression by the Staphylococcus aureus cvfB gene. Infect. Immun. 75:1964-72 |
|---|---|
| Abstract |
We previously reported that the cvfB gene (SA1223) of Staphylococcus aureus is responsible for the virulence of this pathogenic bacterium. We show here that the cvfB gene regulates exoprotein gene expression. In a cvfB gene deletion mutant, hemolysin, DNase, and protease production were decreased, whereas protein A expression was increased. The amount of RNAIII, the transcript from the P3 promoter in the agr locus that regulates the expression of various virulence factors, was also reduced in the cvfB mutant. In addition, P2 and P3 promoter activity in the agr locus was decreased in the mutant. Under the genetic background of the agr-null mutation, cvfB gene disruption decreased the production levels of DNase and protease. Moreover, the cvfB and agr double mutant was less virulent than the agr mutant in silkworms. These results suggest that the cvfB gene product contributes to the expression of virulence factors and to pathogenicity via both agr-dependent and agr-independent pathways. |
| Links |
PubMed PMC1865683 Online version:10.1128/IAI.01552-06 |
| Keywords |
Animals; Bacterial Proteins/biosynthesis; Bacterial Proteins/genetics; Bacterial Proteins/physiology; Bombyx/microbiology; Deoxyribonucleases/biosynthesis; Female; Gene Deletion; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genes, Regulator; Hemolysin Proteins/biosynthesis; Mice; Peptide Hydrolases/biosynthesis; RNA, Antisense/biosynthesis; RNA, Bacterial/biosynthesis; Staphylococcal Protein A/biosynthesis; Staphylococcus aureus/genetics; Staphylococcus aureus/metabolism; Staphylococcus aureus/pathogenicity; Trans-Activators/genetics; Trans-Activators/physiology; Virulence/genetics; Virulence Factors/biosynthesis; Virulence Factors/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0035592: establishment of protein localization in extracellular region |
ECO:0000315: |
P |
Table 3. Decreased exotoxin activity in the cvfB mutant. |
complete | ||||
See also
References
See Help:References for how to manage references in GONUTS.
