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PMID:17266933
| Citation |
Plongthongkum, N, Kullawong, N, Panyim, S and Tirasophon, W (2007) Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 354:789-94 |
|---|---|
| Abstract |
The ability of cells to survive and recover from deteriorating effects of endoplasmic reticulum (ER) stress relies on the unfolded protein response (UPR). The signaling pathway of Ire1p mediate mRNA splicing plays diverge role in UPR response in different organisms from yeast to mammals. Here, we report that Ire1p mediated XBP1 mRNA splicing mechanism is extremely conserved and exerts a critical role for modulating Xbp1 protein synthesis in Drosophila melanogaster. This system is operative in Drosophila S2 cells as a prominent mechanism to mediate transcriptional activation of UPR responsive genes during ER stress. |
| Links |
PubMed Online version:10.1016/j.bbrc.2007.01.056 |
| Keywords |
Animals; Base Sequence; Cells, Cultured; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Drosophila melanogaster; Endoplasmic Reticulum/metabolism; Endoribonucleases/physiology; Molecular Chaperones/metabolism; Oxidative Stress/physiology; RNA Splicing; Saccharomyces cerevisiae Proteins/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
DROME:A8JR46 |
involved_in |
GO:0043484: regulation of RNA splicing |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:A8JR46 |
enables |
GO:0004521: endoribonuclease activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
DROME:A8JR46 |
involved_in |
GO:0030968: endoplasmic reticulum unfolded protein response |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:A8JR46 |
involved_in |
GO:0034976: response to endoplasmic reticulum stress |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:Q5BI44 |
involved_in |
GO:0030968: endoplasmic reticulum unfolded protein response |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:Q5BI44 |
involved_in |
GO:0034976: response to endoplasmic reticulum stress |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:Q5BI44 |
involved_in |
GO:0006990: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:Q8MLW7 |
involved_in |
GO:0030968: endoplasmic reticulum unfolded protein response |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:Q8MLW7 |
involved_in |
GO:0034976: response to endoplasmic reticulum stress |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:Q8MLW7 |
involved_in |
GO:0006990: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
See also
References
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