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PMID:17266933

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Citation

Plongthongkum, N, Kullawong, N, Panyim, S and Tirasophon, W (2007) Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 354:789-94

Abstract

The ability of cells to survive and recover from deteriorating effects of endoplasmic reticulum (ER) stress relies on the unfolded protein response (UPR). The signaling pathway of Ire1p mediate mRNA splicing plays diverge role in UPR response in different organisms from yeast to mammals. Here, we report that Ire1p mediated XBP1 mRNA splicing mechanism is extremely conserved and exerts a critical role for modulating Xbp1 protein synthesis in Drosophila melanogaster. This system is operative in Drosophila S2 cells as a prominent mechanism to mediate transcriptional activation of UPR responsive genes during ER stress.

Links

PubMed Online version:10.1016/j.bbrc.2007.01.056

Keywords

Animals; Base Sequence; Cells, Cultured; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Drosophila melanogaster; Endoplasmic Reticulum/metabolism; Endoribonucleases/physiology; Molecular Chaperones/metabolism; Oxidative Stress/physiology; RNA Splicing; Saccharomyces cerevisiae Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A8JR46

involved_in

GO:0043484: regulation of RNA splicing

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:A8JR46

enables

GO:0004521: endoribonuclease activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:A8JR46

involved_in

GO:0030968: endoplasmic reticulum unfolded protein response

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:A8JR46

involved_in

GO:0034976: response to endoplasmic reticulum stress

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q5BI44

involved_in

GO:0030968: endoplasmic reticulum unfolded protein response

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q5BI44

involved_in

GO:0034976: response to endoplasmic reticulum stress

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q5BI44

involved_in

GO:0006990: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8MLW7

involved_in

GO:0030968: endoplasmic reticulum unfolded protein response

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8MLW7

involved_in

GO:0034976: response to endoplasmic reticulum stress

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8MLW7

involved_in

GO:0006990: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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