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PMID:17166233

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Citation

Wu, J, Randle, KE and Wu, LP (2007) ird1 is a Vps15 homologue important for antibacterial immune responses in Drosophila. Cell. Microbiol. 9:1073-85

Abstract

The immune response-deficient 1 (ird1) gene was identified in a forward genetic screen as a novel regulator for the activation of Imd NFkappaB immune signalling pathway in Drosophila. ird1 animals are also more susceptible to Escherichia coli and Micrococcus luteus bacterial infection. ird1 encodes the Drosophila homologue of the Vps15/p150 serine/threonine kinase that regulates a class III phosphoinositide 3-kinase and is necessary for phagosome maturation and starvation-induced autophagy in yeast and mammalian cells. To gain insight into the role of ird1 in the immune response, we examine how amino acid starvation affects the immune signalling pathways in Drosophila. Starvation, in the absence of infection, leads to expression of antimicrobial peptide (AMP) genes and this response is dependent on ird1 and the Imd immune signalling pathway. Starvation, in addition to bacterial infection, suppresses the AMP response in wild-type animals and reduces the ability to survive M. luteus infection. Our results suggest that starvation and innate immune signalling may be intimately linked processes.

Links

PubMed Online version:10.1111/j.1462-5822.2006.00853.x

Keywords

Animals; Antimicrobial Cationic Peptides/genetics; Antimicrobial Cationic Peptides/immunology; Drosophila/genetics; Drosophila/microbiology; Drosophila Proteins/genetics; Drosophila Proteins/immunology; Endosomal Sorting Complexes Required for Transport; Escherichia coli/growth & development; Gene Expression; Glycopeptides/genetics; Glycopeptides/immunology; Micrococcus luteus/growth & development; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/immunology; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/genetics; Signal Transduction/immunology; Vacuolar Sorting Protein VPS15

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A0A0B4KGX5

involved_in

GO:0034198: cellular response to amino acid starvation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:A0A0B4KGX5

involved_in

GO:0002784: regulation of antimicrobial peptide production

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:E1JIG3

involved_in

GO:0034198: cellular response to amino acid starvation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:E1JIG3

involved_in

GO:0002784: regulation of antimicrobial peptide production

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:NFKB1

involved_in

GO:0034198: cellular response to amino acid starvation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q961J4

involved_in

GO:0034198: cellular response to amino acid starvation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q961J4

involved_in

GO:0002784: regulation of antimicrobial peptide production

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VHH2

involved_in

GO:0034198: cellular response to amino acid starvation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VHH2

involved_in

GO:0002784: regulation of antimicrobial peptide production

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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