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PMID:17113384

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Citation

Lovegrove, B, Simões, S, Rivas, ML, Sotillos, S, Johnson, K, Knust, E, Jacinto, A and Hombría, JC (2006) Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila. Curr. Biol. 16:2206-16

Abstract

Hox genes control animal body plans by directing the morphogenesis of segment-specific structures. As transcription factors, HOX proteins achieve this through the activation of downstream target genes. Much research has been devoted to the search for these targets and the characterization of their roles in organogenesis. This has shown that the direct targets of Hox activation are often transcription factors or signaling molecules, which form hierarchical genetic networks directing the morphogenesis of particular organs. Importantly, very few of the direct Hox targets known are "realizator" genes involved directly in the cellular processes of organogenesis.

Links

PubMed Online version:10.1016/j.cub.2006.09.029

Keywords

Animals; Binding Sites/genetics; Cell Adhesion/physiology; Cell Polarity/physiology; Cytoskeleton/physiology; DNA Primers; Drosophila/growth & development; Drosophila Proteins/metabolism; Gene Expression Regulation, Developmental/physiology; Homeodomain Proteins/metabolism; Larva/growth & development; Mutagenesis, Site-Directed; Organogenesis/physiology; RNA Interference; Signal Transduction/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A0A0B4LHM7

involved_in

GO:0007424: open tracheal system development

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0003391

P

Seeded From UniProt

complete

DROME:A8JR05

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:C6SUV2

involved_in

GO:0007424: open tracheal system development

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0003391

P

Seeded From UniProt

complete

DROME:ABDB

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CRB

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:RAC1

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:RHO1

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CADE

enables

GO:0005509: calcium ion binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:CADE

involved_in

GO:0016339: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CADE

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CADE

involved_in

GO:0007156: homophilic cell adhesion via plasma membrane adhesion molecules

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CADE

enables

GO:0042803: protein homodimerization activity

ECO:0000353: physical interaction evidence used in manual assertion

FB:FBgn0003391

F

Seeded From UniProt

complete

DROME:CADE

involved_in

GO:0044331: cell-cell adhesion mediated by cadherin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IGX4

enables

GO:0005509: calcium ion binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:Q8IGX4

involved_in

GO:0016339: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IGX4

involved_in

GO:0007156: homophilic cell adhesion via plasma membrane adhesion molecules

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IGX4

enables

GO:0042803: protein homodimerization activity

ECO:0000353: physical interaction evidence used in manual assertion

FB:FBgn0036715

F

Seeded From UniProt

complete

DROME:Q8IGX4

located_in

GO:0016324: apical plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q8IGX4

involved_in

GO:0044331: cell-cell adhesion mediated by cadherin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8SY28

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VBV6

involved_in

GO:0007424: open tracheal system development

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0003391

P

Seeded From UniProt

complete

DROME:Q9VFH5

involved_in

GO:0007424: open tracheal system development

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0003391

P

Seeded From UniProt

complete

DROME:Q9VFK2

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VVG0

enables

GO:0005509: calcium ion binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:Q9VVG0

involved_in

GO:0016339: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VVG0

involved_in

GO:0007156: homophilic cell adhesion via plasma membrane adhesion molecules

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VVG0

enables

GO:0042803: protein homodimerization activity

ECO:0000353: physical interaction evidence used in manual assertion

FB:FBgn0036715

F

Seeded From UniProt

complete

DROME:Q9VVG0

located_in

GO:0016324: apical plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q9VVG0

involved_in

GO:0044331: cell-cell adhesion mediated by cadherin

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DOME

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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