GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:17043110

From GONUTS
Jump to: navigation, search
Citation

Smolik, S and Jones, K (2007) Drosophila dCBP is involved in establishing the DNA replication checkpoint. Mol. Cell. Biol. 27:135-46

Abstract

The CBP/p300 family of proteins comprises related acetyltransferases that coactivate signal-responsive transcription. Recent evidence suggests that p300/CBP may also interact directly with complexes that mediate different aspects of DNA metabolism such as replication and repair. In this report, we show that loss of dCBP in Drosophila cells and eye discs results in a defect in the cell cycle arrest induced by stalled DNA replication. We show that dCBP and the checkpoint kinase Mei-41 can be found together in a complex and, furthermore, that dCBP has a genetic interaction with mei-41 in the response to stalled DNA replication. These observations suggest a broader role for the p300/CBP acetyltransferases in the modulation of chromatin structure and function during DNA metabolic events as well as for transcription.

Links

PubMed PMC1800657 Online version:10.1128/MCB.01283-06

Keywords

Animals; Cell Cycle Proteins/metabolism; Chromatin/chemistry; DNA Repair; DNA Replication; Drosophila Proteins/metabolism; Drosophila melanogaster; Genome; Heterozygote; Homozygote; Models, Genetic; Protein-Serine-Threonine Kinases/metabolism; RNA, Small Interfering; S Phase; Signal Transduction; Transcription, Genetic; p300-CBP Transcription Factors/metabolism; p300-CBP Transcription Factors/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:M9MS40

involved_in

GO:0000076: DNA replication checkpoint signaling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:M9PH39

involved_in

GO:0000076: DNA replication checkpoint signaling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:O01368

involved_in

GO:0000076: DNA replication checkpoint signaling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q95TP4

involved_in

GO:0000076: DNA replication checkpoint signaling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:ATR

involved_in

GO:0000076: DNA replication checkpoint signaling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9W321

involved_in

GO:0000076: DNA replication checkpoint signaling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.