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PMID:17020544

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Citation

Chen, W, Honma, K, Sharma, A and Kuramitsu, HK (2006) A universal stress protein of Porphyromonas gingivalis is involved in stress responses and biofilm formation. FEMS Microbiol. Lett. 264:15-21

Abstract

Porphyromonas gingivalis is recognized as one of the major periodontal pathogens in subgingival plaque, which is implicated in the progression of chronic periodontal disease. We analyzed the role of upsA in P. gingivalis 381 and its uspA-deficient mutant CW301 under various stress conditions. In general, the uspA mutant was less tolerant to a variety of environmental stresses relative to the parental strain. In addition, gene expression of uspA is upregulated during biofilm formation. Biofilm formation of the uspA mutant was also less than that of strain 381. In conclusion, the uspA gene affecting the stress responses of P. gingivalis is required for optimal biofilm formation.

Links

PubMed Online version:10.1111/j.1574-6968.2006.00426.x

Keywords

Anti-Bacterial Agents/pharmacology; Bacterial Proteins/genetics; Bacterial Proteins/physiology; Biofilms/growth & development; Gene Expression Regulation, Bacterial; Gene Silencing; Heat-Shock Proteins/genetics; Heat-Shock Proteins/physiology; Hot Temperature; Microbial Sensitivity Tests; Oxidative Stress; Porphyromonas gingivalis/drug effects; Porphyromonas gingivalis/metabolism; Porphyromonas gingivalis/physiology; Tetracycline/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

PORGN:A0A0E2LMN8

GO:0044011: single-species biofilm formation on inanimate substrate

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Figure 5. Biofilm phenotype analysis by CLSM shows Porphyromonas gingivalis (strain 381) formed more abundant biofilms with bacterial cell clusters than mutant uspA* (CW301). *Universal Stress Protein

complete
CACAO 12310

Notes

See also

References

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