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PMID:16960009

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Citation

Masly, JP, Jones, CD, Noor, MA, Locke, J and Orr, HA (2006) Gene transposition as a cause of hybrid sterility in Drosophila. Science 313:1448-50

Abstract

We describe reproductive isolation caused by a gene transposition. In certain Drosophila melanogaster-D. simulans hybrids, hybrid male sterility is caused by the lack of a single-copy gene essential for male fertility, JYAlpha. This gene is located on the fourth chromosome of D. melanogaster but on the third chromosome of D. simulans. Genomic and molecular analyses show that JYAlpha transposed to the third chromosome during the evolutionary history of the D. simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution.

Links

PubMed Online version:10.1126/science.1128721

Keywords

Animals; Chromosome Mapping; Chromosomes/genetics; Drosophila/enzymology; Drosophila/genetics; Drosophila/physiology; Drosophila melanogaster/enzymology; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Evolution, Molecular; Female; Fertility/genetics; Gene Dosage; Genes, Insect; Hybridization, Genetic; Male; Mutation; Recombination, Genetic; Reproduction/genetics; Sodium-Potassium-Exchanging ATPase/genetics; Sperm Motility

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A8QI34

involved_in

GO:0030317: flagellated sperm motility

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9U458

involved_in

GO:0030317: flagellated sperm motility

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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