GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:16952559

From GONUTS
Jump to: navigation, search
Citation

Masyuk, AI, Masyuk, TV, Splinter, PL, Huang, BQ, Stroope, AJ and LaRusso, NF (2006) Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Gastroenterology 131:911-20

Abstract

Cholangiocytes have primary cilia extending from the apical plasma membrane into the ductal lumen. While the physiologic significance of cholangiocyte cilia is unknown, studies in renal epithelia suggest that primary cilia possess sensory functions. Here, we tested the hypothesis that cholangiocyte cilia are sensory organelles that detect and transmit luminal bile flow stimuli into intracellular Ca2+ ([Ca2+]i) and adenosine 3',5'-cyclic monophosphate (cAMP) signaling.

Links

PubMed PMC1866168 Online version:10.1053/j.gastro.2006.07.003

Keywords

Animals; Bile Ducts, Intrahepatic/metabolism; Bile Ducts, Intrahepatic/ultrastructure; Calcium/metabolism; Calcium Channels/metabolism; Cilia/metabolism; Cilia/ultrastructure; Cyclic AMP/metabolism; Intracellular Fluid/metabolism; Male; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Rats; Rats, Inbred F344; Signal Transduction/physiology; TRPP Cation Channels/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:D4A5F1

involved_in

GO:0007204: positive regulation of cytosolic calcium ion concentration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:F1MAD3

involved_in

GO:0007204: positive regulation of cytosolic calcium ion concentration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

See Help:References for how to manage references in GONUTS.