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PMID:16943278

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Citation

Miura, S, Davis, S, Klingensmith, J and Mishina, Y (2006) BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development 133:3767-75

Abstract

Bmpr1a encodes the BMP type IA receptor for bone morphogenetic proteins (BMPs), including 2 and 4. Here, we use mosaic inactivation of Bmpr1a in the epiblast of the mouse embryo (Bmpr-MORE embryos) to assess functions of this gene in mesoderm development. Unlike Bmpr1a-null embryos, which fail to gastrulate, Bmpr-MORE embryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character within the primitive streak, resulting in a lateral expansion of somitic mesoderm to form multiple columns. Inhibition of FGF signaling restores the normal timing of recruitment of prospective paraxial mesoderm and partially rescues the development of somites. This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development.

Links

PubMed Online version:10.1242/dev.02552

Keywords

Animals; Body Patterning/genetics; Bone Morphogenetic Protein Receptors, Type I/antagonists & inhibitors; Bone Morphogenetic Protein Receptors, Type I/genetics; Bone Morphogenetic Protein Receptors, Type I/physiology; Bone Morphogenetic Proteins/physiology; Embryonic Development/genetics; Fibroblast Growth Factors/antagonists & inhibitors; Fibroblast Growth Factors/genetics; Fibroblast Growth Factors/physiology; Mesoderm/cytology; Mesoderm/physiology; Mice; Mice, Mutant Strains; Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors; Receptor, Fibroblast Growth Factor, Type 1/genetics; Receptor, Fibroblast Growth Factor, Type 1/physiology; Signal Transduction/genetics; Somites/cytology; Somites/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:FGFR1

involved_in

GO:0048339: paraxial mesoderm development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1338938

P

Seeded From UniProt

complete

MOUSE:FGFR1

involved_in

GO:0048378: regulation of lateral mesodermal cell fate specification

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1338938

P

Seeded From UniProt

complete

MOUSE:BMR1A

involved_in

GO:0048339: paraxial mesoderm development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:95522

P

Seeded From UniProt

complete

MOUSE:BMR1A

involved_in

GO:0048378: regulation of lateral mesodermal cell fate specification

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:95522

P

Seeded From UniProt

complete

MOUSE:BMR1A

involved_in

GO:0048339: paraxial mesoderm development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158343

P

Seeded From UniProt

complete

MOUSE:BMR1A

involved_in

GO:0048352: paraxial mesoderm structural organization

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158343

P

Seeded From UniProt

complete

MOUSE:BMR1A

involved_in

GO:0048368: lateral mesoderm development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158343

P

Seeded From UniProt

complete

MOUSE:BMR1A

involved_in

GO:0060896: neural plate pattern specification

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158343

P

Seeded From UniProt

complete

MOUSE:BMR1A

involved_in

GO:0060914: heart formation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158343

P

Seeded From UniProt

complete

MOUSE:BMR1A

involved_in

GO:0021998: neural plate mediolateral regionalization

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158343

P

Seeded From UniProt

complete

MOUSE:BMR1A

involved_in

GO:0030509: BMP signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158343

P

Seeded From UniProt

complete

MOUSE:BMR1A

involved_in

GO:0001756: somitogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2158343

P

Seeded From UniProt

complete


See also

References

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