GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16943278
| Citation |
Miura, S, Davis, S, Klingensmith, J and Mishina, Y (2006) BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development 133:3767-75 |
|---|---|
| Abstract |
Bmpr1a encodes the BMP type IA receptor for bone morphogenetic proteins (BMPs), including 2 and 4. Here, we use mosaic inactivation of Bmpr1a in the epiblast of the mouse embryo (Bmpr-MORE embryos) to assess functions of this gene in mesoderm development. Unlike Bmpr1a-null embryos, which fail to gastrulate, Bmpr-MORE embryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character within the primitive streak, resulting in a lateral expansion of somitic mesoderm to form multiple columns. Inhibition of FGF signaling restores the normal timing of recruitment of prospective paraxial mesoderm and partially rescues the development of somites. This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development. |
| Links |
PubMed Online version:10.1242/dev.02552 |
| Keywords |
Animals; Body Patterning/genetics; Bone Morphogenetic Protein Receptors, Type I/antagonists & inhibitors; Bone Morphogenetic Protein Receptors, Type I/genetics; Bone Morphogenetic Protein Receptors, Type I/physiology; Bone Morphogenetic Proteins/physiology; Embryonic Development/genetics; Fibroblast Growth Factors/antagonists & inhibitors; Fibroblast Growth Factors/genetics; Fibroblast Growth Factors/physiology; Mesoderm/cytology; Mesoderm/physiology; Mice; Mice, Mutant Strains; Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors; Receptor, Fibroblast Growth Factor, Type 1/genetics; Receptor, Fibroblast Growth Factor, Type 1/physiology; Signal Transduction/genetics; Somites/cytology; Somites/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
MOUSE:FGFR1 |
involved_in |
GO:0048339: paraxial mesoderm development |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:1338938 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:FGFR1 |
involved_in |
GO:0048378: regulation of lateral mesodermal cell fate specification |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:1338938 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:BMR1A |
involved_in |
GO:0048339: paraxial mesoderm development |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:95522 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:BMR1A |
involved_in |
GO:0048378: regulation of lateral mesodermal cell fate specification |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:95522 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:BMR1A |
involved_in |
GO:0048339: paraxial mesoderm development |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:2158343 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:BMR1A |
involved_in |
GO:0048352: paraxial mesoderm structural organization |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:2158343 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:BMR1A |
involved_in |
GO:0048368: lateral mesoderm development |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:2158343 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:BMR1A |
involved_in |
GO:0060896: neural plate pattern specification |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:2158343 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:BMR1A |
involved_in |
GO:0060914: heart formation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:2158343 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:BMR1A |
involved_in |
GO:0021998: neural plate mediolateral regionalization |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:2158343 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:BMR1A |
involved_in |
GO:0030509: BMP signaling pathway |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:2158343 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:BMR1A |
involved_in |
GO:0001756: somitogenesis |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:2158343 |
P |
Seeded From UniProt |
complete | |
See also
References
See Help:References for how to manage references in GONUTS.
