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PMID:16938278

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Citation

Konishi, Y, Ikeda, K, Iwakura, Y and Kawakami, K (2006) Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. Brain Res. 1116:93-102

Abstract

Survival of sensory neurons is tightly regulated in cell-type and developmental-stage-specific manners. The transcriptional regulatory mechanisms underlying this regulation remain to be elucidated. In the present study, we investigated the role of Six1 and Six4 in the development of trigeminal ganglia. Abundant expression of Six1 and Six4 was noted in sensory neurons during early trigeminal gangliogenesis. Loss of both Six1 and Six4 in mice caused severe defects in the trigeminal ganglia, wherein massive apoptosis accompanied by activation of caspase-3 was observed at early but not late stages of gangliogenesis. In Six1(-/-)Six4(-/-) mice, trigeminal sensory neurons were generated, but showed reduced expression of Bcl-x compared with the wild-type mice. Accordingly, neurons from the deficient mice could not survive in culture even in the presence of neurotrophins. Our results suggest a cell-intrinsic role of Six1 and Six4 in the survival of early-generated trigeminal sensory neurons.

Links

PubMed Online version:10.1016/j.brainres.2006.07.103

Keywords

Animals; Cell Survival/genetics; Homeodomain Proteins/genetics; Homeodomain Proteins/physiology; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factors/physiology; Neurons, Afferent/metabolism; Neurons, Afferent/physiology; Transcription Factors/genetics; Transcription Factors/physiology; Trigeminal Ganglion/cytology; Trigeminal Ganglion/growth & development; Trigeminal Ganglion/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SIX4

involved_in

GO:0061551: trigeminal ganglion development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SIX4

involved_in

GO:0048699: generation of neurons

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SIX4

involved_in

GO:0043524: negative regulation of neuron apoptotic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SIX1

involved_in

GO:0061551: trigeminal ganglion development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SIX1

involved_in

GO:0048699: generation of neurons

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SIX1

involved_in

GO:0043524: negative regulation of neuron apoptotic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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