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PMID:1690992

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Citation

Thompson, J, Koumari, R, Wagner, K, Barnert, S, Schleussner, C, Schrewe, H, Zimmermann, W, Müller, G, Schempp, W and Zaninetta, D (1990) The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. Biochem. Biophys. Res. Commun. 167:848-59

Abstract

The pregnancy-specific glycoprotein (PSG) genes encode a group of proteins which are found in large amounts in placenta and maternal serum. In situ hybridization analyses of metaphase chromosomes reveal that all the human pregnancy-specific glycoprotein (PSG) genes are located on the long arm of chromosome 19 (19q13.2-13.3), overlapping the region containing the closely-related carcinoembryonic antigen (CEA) gene subgroup. Higher resolution analyses indicate that the PSG genes are closely linked within an 800kb SacII restriction endonuclease fragment. This has been confirmed through restriction endonuclease mapping and DNA sequence analyses of isolated genomic clones, which show that at least some of these genes are located in very close proximity. Further, these studies have helped to identify a new member of the PSG gene subfamily (PSG7). DNA/RNA hybridization analyses, using gene-specific oligonucleotide probes based on published sequences, showed that five from six PSG genes tested are coordinately transcribed in the placenta. Due to the close proximity of these genes and their coordinated expression pattern, common transcriptional regulatory elements may exist.

Links

PubMed

Keywords

Base Sequence; Carcinoembryonic Antigen/genetics; Cell Line; Chromosomes, Human, Pair 19; Cloning, Molecular; DNA/genetics; DNA/isolation & purification; Female; Genes; Genetic Linkage; Genomic Library; Humans; Molecular Sequence Data; Molecular Weight; Nucleic Acid Hybridization; Oligonucleotide Probes; Placenta/metabolism; Pregnancy; Pregnancy Proteins/genetics; RNA/genetics; RNA/isolation & purification; Restriction Mapping

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:PSG9

involved_in

GO:0007565: female pregnancy

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PSG4

involved_in

GO:0007565: female pregnancy

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PSG7

involved_in

GO:0007565: female pregnancy

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PSG5

involved_in

GO:0007565: female pregnancy

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PSG11

involved_in

GO:0007565: female pregnancy

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PSG6

involved_in

GO:0007565: female pregnancy

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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