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PMID:16902415

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Citation

Lee, L, DeBono, CA, Campagna, DR, Young, DC, Moody, DB and Fleming, MD (2007) Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin. J. Invest. Dermatol. 127:16-23

Abstract

Proper fatty acid metabolism is critical for hair and skin development and maintenance. The acyl-CoA binding protein (Acbp) is a widely expressed protein that binds long-chain fatty acyl-CoA esters and plays a role in fatty acyl-CoA transport and pool formation. However, loss of function of Acbp in the whole animal has not been investigated. Here, we show that deletion of Acbp in mouse results in sebocyte hyperplasia and sparse, matted hair with a greasy appearance. Consistent with these gross abnormalities, Acbp is highly expressed in the pilosebaceous units of mouse skin as determined by Northern analysis and in situ hybridization. Loss of Acbp also results in fatty acid metabolism abnormalities, with hair lipid profiles showing altered levels of triacylglycerols and nearly co-migrating lipids. These data suggest that Acbp plays a role in triacylglycerol biosynthesis, and that regulation of this process is important for proper hair and skin development and maintenance in the mouse.

Links

PubMed PMC1847342 Online version:10.1038/sj.jid.5700511

Keywords

Animals; Diazepam Binding Inhibitor/analysis; Diazepam Binding Inhibitor/metabolism; Fatty Acids/metabolism; Hair/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; PPAR gamma/genetics; PPAR gamma/physiology; Skin/metabolism; Triglycerides/biosynthesis

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:ACBP

acts_upstream_of_or_within

GO:0001942: hair follicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • results_in_development_of:(EMAPA:35246)

Seeded From UniProt

complete

MOUSE:ACBP

acts_upstream_of_or_within

GO:0006641: triglyceride metabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(EMAPA:35246)

Seeded From UniProt

complete

MOUSE:ACBP

acts_upstream_of_or_within

GO:0043588: skin development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • results_in_development_of:(EMAPA:36582)

Seeded From UniProt

complete


See also

References

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