PMID:16902139

Citation	Föger, N, Rangell, L, Danilenko, DM and Chan, AC (2006) Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science 313:839-42
Abstract	The evolutionarily conserved actin-related protein (Arp2/3) complex is a key component of actin filament networks that is dynamically regulated by nucleation-promoting and inhibitory factors. Although much is known about actin assembly, the physiologic functions of inhibitory proteins are unclear. We generated coronin 1-/- mice and found that coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism. Whereas coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T cells. Moreover, actin dynamics, through a mitochondrial pathway, was linked to lymphocyte homeostasis.
Links	PubMed Online version:10.1126/science.1130563
Keywords	Actin-Related Protein 2-3 Complex/metabolism; Actins/metabolism; Adoptive Transfer; Animals; Apoptosis; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/physiology; Cell Polarity; Cell Survival; Chemotaxis, Leukocyte; Gene Targeting; Homeostasis; Intracellular Membranes/physiology; Lymph Nodes/immunology; Membrane Potentials; Mice; Mice, Inbred C57BL; Microfilament Proteins/genetics; Microfilament Proteins/physiology; Mitochondria/physiology; Receptors, Antigen, T-Cell/immunology; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/physiology; T-Lymphocytes/cytology; T-Lymphocytes/immunology; T-Lymphocytes/physiology; Talin/metabolism
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