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PMID:16835300
| Citation |
Miao, RQ, Gao, Y, Harrison, KD, Prendergast, J, Acevedo, LM, Yu, J, Hu, F, Strittmatter, SM and Sessa, WC (2006) Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 103:10997-1002 |
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| Abstract |
Nogo isoforms (Nogo-A and -B) have been implicated in regulating neural and cardiovascular functions, such as cell spreading and chemotaxis. Unlike the loop domain (Nogo-66) found in all Nogo isoforms that can interact with a neural-specific Nogo-66 receptor, the receptor for the amino terminus of Nogo-B that mediates vascular function is unknown. Here, we identify a previously uncharacterized Nogo-B receptor specific for the amino terminus of Nogo-B and show that Nogo-B receptor localizes with the ligand Nogo-B during VEGF and wound healing angiogenesis in vivo, mediates chemotaxis in a heterologous expression system and chemotaxis, and 3D tube formation in native endothelial cells. Thus, identification of this receptor may lead to the discovery of agonists or antagonists of this pathway to regulate vascular remodeling and angiogenesis. |
| Links |
PubMed PMC1544163 Online version:10.1073/pnas.0602427103 |
| Keywords |
Amino Acid Sequence; Animals; Cell Shape; Cells, Cultured; Cercopithecus aethiops; Chemotaxis; Cricetinae; Endothelial Cells/cytology; Endothelial Cells/metabolism; Humans; Mice; Molecular Sequence Data; Myelin Proteins/genetics; Myelin Proteins/metabolism; Myelin Proteins/pharmacology; Protein Binding; Protein Isoforms/metabolism; Receptors, Cell Surface/chemistry; Receptors, Cell Surface/metabolism |
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| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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