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PMID:16824957

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Citation

Arata, Y, Kouike, H, Zhang, Y, Herman, MA, Okano, H and Sawa, H (2006) Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans. Dev. Cell 11:105-15

Abstract

Asymmetric cell division is a mechanism for achieving cellular diversity. In C. elegans, many asymmetric cell divisions are controlled by the Wnt-MAPK pathway through POP-1/TCF. It is poorly understood, however, how POP-1 determines the specific fates of daughter cells. We found that nob-1/Hox, ceh-20/Pbx, and a Meis-related gene, psa-3, are required for asymmetric division of the T hypodermal cell. psa-3 expression was asymmetric between the T cell daughters, and it was regulated by POP-1 through a POP-1 binding site in the psa-3 gene. psa-3 expression was also regulated by NOB-1 and CEH-20 through a NOB-1 binding sequence in a psa-3 intron. PSA-3 can bind CEH-20 and function after the T cell division to promote the proper fate of the daughter cell. These results indicate that cooperation between Wnt signaling and a Hox protein functions to determine the specific fate of a daughter cell.

Links

PubMed Online version:10.1016/j.devcel.2006.04.020

Keywords

Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Animals, Genetically Modified; Binding Sites/genetics; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans Proteins/physiology; Cell Division; Genes, Helminth; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Homeodomain Proteins/physiology; Introns; Molecular Sequence Data; Sequence Homology, Amino Acid; Signal Transduction; Transcription Factors/genetics; Transcription Factors/metabolism; Wnt Proteins/genetics; Wnt Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:NOB1

involved_in

GO:0009786: regulation of asymmetric cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(WBbt:0004944)|occurs_in:(WBbt:0004946)

Seeded From UniProt

complete

CAEEL:NOB1

enables

GO:0043565: sequence-specific DNA binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

CAEEL:HM20

involved_in

GO:0009786: regulation of asymmetric cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(WBbt:0004944)|occurs_in:(WBbt:0004946)

Seeded From UniProt

complete

CAEEL:HM20

enables

GO:0001223: transcription coactivator binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q0G825

F

Seeded From UniProt

complete

CAEEL:Q0G825

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:Q0G825

involved_in

GO:0009786: regulation of asymmetric cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(WBbt:0004944)|occurs_in:(WBbt:0004946)

Seeded From UniProt

complete

CAEEL:Q0G825

enables

GO:0001223: transcription coactivator binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P41779

F

Seeded From UniProt

complete


See also

References

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