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PMID:16822982

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Citation

Hong, ST, Bang, S, Paik, D, Kang, J, Hwang, S, Jeon, K, Chun, B, Hyun, S, Lee, Y and Kim, J (2006) Histamine and its receptors modulate temperature-preference behaviors in Drosophila. J. Neurosci. 26:7245-56

Abstract

Temperature profoundly influences various life phenomena, and most animals have developed mechanisms to respond properly to environmental temperature fluctuations. To identify genes involved in sensing ambient temperature and in responding to its change, >27,000 independent P-element insertion mutants of Drosophila were screened. As a result, we found that defects in the genes encoding for proteins involved in histamine signaling [histidine decarboxylase (hdc), histamine-gated chloride channel subunit 1 (hisCl1), ora transientless (ort)] cause abnormal temperature preferences. The abnormal preferences shown in these mutants were restored by genetic and pharmacological rescue and could be reproduced in wild type using the histamine receptor inhibitors cimetidine and hydroxyzine. Spatial expression of these genes was observed in various brain regions including pars intercerebralis, fan-shaped body, and circadian clock neurons but not in dTRPA1-expressing neurons, an essential element for thermotaxis. We also found that the histaminergic mutants showed reduced tolerance for high temperature and enhanced tolerance for cold temperature. Together, these results suggest that histamine signaling may have important roles in modulating temperature preference and in controlling tolerance of low and high temperature.

Links

PubMed Online version:10.1523/JNEUROSCI.5426-05.2006

Keywords

Animals; Behavior, Animal/physiology; Chloride Channels/genetics; Chloride Channels/metabolism; Cold Temperature; Discrimination (Psychology)/physiology; Drosophila/genetics; Drosophila/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Histamine/metabolism; Histidine Decarboxylase/genetics; Histidine Decarboxylase/metabolism; Hot Temperature; Mutagenesis; Receptors, Histamine/genetics; Receptors, Histamine/metabolism; Signal Transduction/physiology; Thermosensing/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A1KYB3

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:A1KYB4

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:A1KYB5

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:E1JII9

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DCHS

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8T9R9

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8WS32

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q95T69

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VDU9

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VGI0

involved_in

GO:0043052: thermotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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