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PMID:16815307

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Citation

Nomura, R, Kamei, E, Hotta, Y, Konishi, M, Miyake, A and Itoh, N (2006) Fgf16 is essential for pectoral fin bud formation in zebrafish. Biochem. Biophys. Res. Commun. 347:340-6

Abstract

Zebrafish pectoral fin bud formation is an excellent model for studying morphogenesis. Fibroblast growth factors (Fgfs) and sonic hedgehog (shh) are essential for pectoral fin bud formation. We found that Fgf16 was expressed in the apical ectodermal ridge (AER) of fin buds. A knockdown of Fgf16 function resulted in no fin bud outgrowth. Fgf16 is required for cell proliferation and differentiation in the mesenchyme and the AER of the fin buds, respectively. Fgf16 functions downstream of Fgf10, a mesenchymal factor, signaling to induce the expression of Fgf4 and Fgf8 in the AER. Fgf16 in the AER and shh in the zone of polarizing activity (ZPA) interact to induce and/or maintain each other's expression. These findings have revealed that Fgf16, a newly identified AER factor, plays a crucial role in pectoral fin bud outgrowth by mediating the interactions of AER-mesenchyme and AER-ZPA.

Links

PubMed Online version:10.1016/j.bbrc.2006.06.108

Keywords

Animals; Fibroblast Growth Factors/chemistry; Fibroblast Growth Factors/isolation & purification; Fibroblast Growth Factors/metabolism; Gene Expression Regulation, Developmental/physiology; Limb Buds/anatomy & histology; Limb Buds/embryology; Limb Buds/physiology; Organ Specificity; Organogenesis/physiology; Tissue Distribution; Zebrafish/anatomy & histology; Zebrafish/embryology; Zebrafish/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:FGF16

involved_in

GO:0008283: cell population proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060831-1

P

Seeded From UniProt

complete

DANRE:FGF16

involved_in

GO:0035138: pectoral fin morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060831-1

P

Seeded From UniProt

complete


See also

References

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