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PMID:16805913

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Citation

Brown, MA, Sims, RJ 3rd, Gottlieb, PD and Tucker, PW (2006) Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol. Cancer 5:26

Abstract

Disrupting the balance of histone lysine methylation alters the expression of genes involved in tumorigenesis including proto-oncogenes and cell cycle regulators. Methylation of lysine residues is commonly catalyzed by a family of proteins that contain the SET domain. Here, we report the identification and characterization of the SET domain-containing protein, Smyd2.

Links

PubMed PMC1524980 Online version:10.1186/1476-4598-5-26

Keywords

Amino Acid Sequence; Animals; Cell Line; Chromatin/chemistry; Gene Expression Regulation; Histone-Lysine N-Methyltransferase/chemistry; Histone-Lysine N-Methyltransferase/physiology; Histones/chemistry; Humans; Lysine/chemistry; Methyltransferases/biosynthesis; Methyltransferases/chemistry; Mice; Molecular Sequence Data; NIH 3T3 Cells; Protein Structure, Tertiary; Repressor Proteins/chemistry; Sequence Homology, Amino Acid

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:HDAC1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q8R5A0

F

Seeded From UniProt

complete

MOUSE:SIN3A

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q8R5A0

F

Seeded From UniProt

complete

MOUSE:SMYD2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q60520

F

Seeded From UniProt

complete

MOUSE:SMYD2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:O09106

F

Seeded From UniProt

complete

MOUSE:SMYD2

involved_in

GO:0018027: peptidyl-lysine dimethylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SMYD2

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SMYD2

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SMYD2

involved_in

GO:0008285: negative regulation of cell population proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SMYD2

enables

GO:0046975: histone methyltransferase activity (H3-K36 specific)

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SMYD3

enables

GO:0018024: histone-lysine N-methyltransferase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete


See also

References

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