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PMID:16647297

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Citation

Rivera, J (2006) Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation. Trends Immunol. 27:251-3

Abstract

The Fc epsilonRI-dependent activation of nuclear factor (NF)kappaB is key for mast-cell cytokine production. The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen receptors in lymphocytes. A recent study reveals that the Bcl10-Malt1 complex promotes mast-cell interleukin-6 and tumor necrosis factor production, independent of degranulation, eicosanoid secretion or survival. The new findings place this complex at the forefront in discriminating between signals required for cytokine production and those required for mast-cell degranulation and eicosanoid production.

Links

PubMed Online version:10.1016/j.it.2006.04.001

Keywords

Adaptor Proteins, Signal Transducing/metabolism; Animals; Cell Degranulation/physiology; Cytokines/biosynthesis; Eicosanoids/biosynthesis; Humans; Mast Cells/immunology; Mast Cells/metabolism; Mast Cells/physiology; Plakins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:BCL10

acts_upstream_of

GO:0032765: positive regulation of mast cell cytokine production

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BCL10

acts_upstream_of

GO:0032761: positive regulation of lymphotoxin A production

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BCL10

acts_upstream_of

GO:0032755: positive regulation of interleukin-6 production

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BCL10

involved_in

GO:0042226: interleukin-6 biosynthetic process

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BCL10

involved_in

GO:0042109: lymphotoxin A biosynthetic process

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BCL10

involved_in

GO:0032765: positive regulation of mast cell cytokine production

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete


See also

References

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