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PMID:16407767

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Citation

Fukuda, M (2006) Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Neuroreport 17:179-82

Abstract

Synaptotagmin IX has been postulated to function as a major Ca2+ sensor for dense-core vesicle exocytosis in neuroendocrine cells. In this study, we investigated the subcellular localization and developmental expression profile of synaptotagmin IX in the mouse brain and found that it is mainly present in the dense-core vesicle fraction, which is devoid of synaptotagmin I and synaptophysin. We also found that the synaptotagmin IX expression level is constant throughout the postnatal development of the mouse brain, whereas the synaptotagmins I, II, III, VI, and XII are upregulated in parallel with synaptogenesis. These findings suggest that synaptotagmin IX regulates the transport of certain vesicles in the brain other than synaptic vesicles.

Links

PubMed

Keywords

Animals; Animals, Newborn; Blotting, Western/methods; Brain/cytology; Brain/metabolism; Embryo, Mammalian; Gene Expression Regulation, Developmental/physiology; Mice; Subcellular Fractions/metabolism; Synaptophysin/metabolism; Synaptotagmin I/metabolism; Synaptotagmin II/metabolism; Synaptotagmins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SYT1

located_in

GO:0008021: synaptic vesicle

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16894)

Seeded From UniProt

complete

MOUSE:DNJC5

located_in

GO:0008021: synaptic vesicle

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16894)

Seeded From UniProt

complete

MOUSE:SYPH

located_in

GO:0008021: synaptic vesicle

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16894)

Seeded From UniProt

complete

MOUSE:SYT5

located_in

GO:0031045: dense core granule

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16894)

Seeded From UniProt

complete

MOUSE:SYT9

located_in

GO:0031045: dense core granule

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16894)

Seeded From UniProt

complete

MOUSE:SYPH

part_of

GO:0008021: synaptic vesicle

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:16894)

Seeded From UniProt

complete

MOUSE:SYT1

part_of

GO:0008021: synaptic vesicle

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:16894)

Seeded From UniProt

complete


See also

References

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