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PMID:1639063

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Citation

Meyerson, M, Enders, GH, Wu, CL, Su, LK, Gorka, C, Nelson, C, Harlow, E and Tsai, LH (1992) A family of human cdc2-related protein kinases. EMBO J. 11:2909-17

Abstract

The p34cdc2 protein kinase is known to regulate important transitions in the eukaryotic cell cycle. We have identified 10 human protein kinases based on their structural relation to p34cdc2. Seven of these kinases are novel and the products of five share greater than 50% amino acid sequence identity with p34cdc2. The seven novel genes are broadly expressed in human cell lines and tissues with each displaying some cell type or tissue specificity. The cdk3 gene, like cdc2 and cdk2, can complement cdc28 mutants of Saccharomyces cerevisiae, suggesting that all three of these protein kinases can play roles in the regulation of the mammalian cell cycle. The identification of a large family of cdc2-related kinases opens the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins.

Links

PubMed PMC556772

Keywords

Amino Acid Sequence; CDC2 Protein Kinase/genetics; Cell Cycle; Cell Line; Cloning, Molecular; DNA, Neoplasm/genetics; DNA, Neoplasm/isolation & purification; Genetic Complementation Test; HeLa Cells; Humans; Molecular Sequence Data; Multigene Family; RNA, Neoplasm/genetics; RNA, Neoplasm/isolation & purification; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Sequence Homology, Nucleic Acid

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:CDK3

involved_in

GO:0008283: cell population proliferation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CDK3

enables

GO:0004693: cyclin-dependent protein serine/threonine kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:CDKL1

enables

GO:0004693: cyclin-dependent protein serine/threonine kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:CDKL1

involved_in

GO:0006468: protein phosphorylation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CDK5

enables

GO:0004672: protein kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:CDK5

enables

GO:0004674: protein serine/threonine kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:CDK17

enables

GO:0004672: protein kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:CDK17

involved_in

GO:0006468: protein phosphorylation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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