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PMID:16376885
| Citation |
Nakai, T, Kato, K, Shinmyo, A and Sekine, M (2006) Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-associated kinases, including plant-specific B-type cyclin-dependent kinase. FEBS Lett. 580:336-40 |
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| Abstract |
Arabidopsis contains seven Kip-related protein (KRP) genes encoding CDK (cyclin-dependent kinase) inhibitors (CKIs), which shares a restricted similarity with mammalian p27Kip1. Here, we analyze the characteristics of the KRPs. Although KRP1-KRP7 interact with active cyclin D2 (CYCD2)/CDKA and CYCD2/CDKB complexes to a similar extent, they inhibit kinase activity to a different extent. Our results suggest that inhibitory activity is related to the binding ability between KRP proteins and cyclin/CDK complexes, but secondary and tertiary structure may be also involved. These data provide the first evidence that KRPs inhibit kinase activity associated with plant-specific CDKB. |
| Links |
PubMed Online version:10.1016/j.febslet.2005.12.018 |
| Keywords |
Arabidopsis/metabolism; Arabidopsis Proteins/metabolism; Cyclin-Dependent Kinase Inhibitor Proteins/metabolism; Cyclin-Dependent Kinase Inhibitor p27/metabolism; Cyclin-Dependent Kinases/metabolism; Cyclins/metabolism; Multiprotein Complexes/metabolism; Protein Structure, Quaternary; Protein Structure, Tertiary; Sequence Homology, Amino Acid |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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