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PMID:16307046
| Citation |
Galenko-Yaroshevskii, AP, Fistunenko, PN and Dukhanin, AS (2005) Kinetics of interaction of local anesthetics with human serum albumin. Bull. Exp. Biol. Med. 140:315-6 |
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| Abstract |
We studied kinetic parameters of interaction of local anesthetics (lidocaine, tetracaine, bupivacaine, and two novel agents with proved local anesthetic potency RU-353 and RU-1117) with human serum albumin. Complexation of local anesthetics with human serum albumin is a time-dependent and reversible process; equilibrium was attained within 1.5-4.5 h depending on chemical nature of local anesthetics. |
| Links | |
| Keywords |
Anesthetics, Local/chemistry; Benzimidazoles/chemistry; Bupivacaine/chemistry; Humans; Kinetics; Lidocaine/chemistry; Serum Albumin/chemistry; Tetracaine/chemistry |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0008144: drug binding |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
See also
References
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