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PMID:16289899

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Citation

Winther, AM, Acebes, A and Ferrús, A (2006) Tachykinin-related peptides modulate odor perception and locomotor activity in Drosophila. Mol. Cell. Neurosci. 31:399-406

Abstract

The invertebrate tachykinin-related peptides (TKRPs) constitute a conserved family, structurally related to the mammalian tachykinins, including members such as substance P and neurokinins A and B. Although their expression has been documented in the brains of insects and mammals, their neural functions remain largely unknown, particularly in behavior. Here, we have studied the role of TKRPs in Drosophila. We have analyzed the olfactory perception and the locomotor activity of individuals in which TKRPs are eliminated in the nervous system specifically, by using RNAi constructs to silence gene expression. The perception of specific odorants and concentrations is modified towards a loss of sensitivity, thus resulting in a significant change of the behavioral response towards indifference. In locomotion assays, the TKRP-deficient flies show hyperactivity. We conclude that these peptides are modulators of olfactory perception and locomotion activity in agreement with their abundant expression in the olfactory lobes and central complex. In these brain centers, TKRPs seem to enhance the regulatory inhibition of the neurons in which they are expressed.

Links

PubMed Online version:10.1016/j.mcn.2005.10.010

Keywords

Animals; Behavior, Animal/physiology; Brain/growth & development; Brain/metabolism; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Hyperkinesis/genetics; Hyperkinesis/metabolism; Hyperkinesis/physiopathology; Larva/genetics; Larva/metabolism; Motor Activity/genetics; Neural Inhibition/genetics; Neurons/metabolism; Odors; Olfactory Pathways/growth & development; Olfactory Pathways/metabolism; Olfactory Pathways/physiopathology; RNA Interference; Smell/genetics; Tachykinins/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:TACHY

involved_in

GO:0007628: adult walking behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:TACHY

involved_in

GO:0007608: sensory perception of smell

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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