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PMID:16289828

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Citation

Christie, BR, Li, AM, Redila, VA, Booth, H, Wong, BK, Eadie, BD, Ernst, C and Simpson, EM (2006) Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus. Neuroscience 137:1031-7

Abstract

The spontaneous or targeted deletion of the nuclear receptor transcription factor Nr2e1 produces a mouse that shows hypoplasia of the hippocampal formation and reduced neurogenesis in adult mice. In these studies we show that hippocampal synaptic transmission appears normal in the dentate gyrus and cornu ammonis 1 subfields of adult mice that lack Nr2e1 (Nr2e1-/-), and that fEPSP shape, paired-pulse responses, and short-term plasticity are not substantially altered in either subfield. In contrast, the expression of long-term potentiation is selectively impaired in the dentate gyrus, and not in the cornu ammonis 1 subfield. Golgi analysis revealed that there was a significant reduction in both dendritic branching and dendritic length that was specific to dentate gyrus granule cells in the Nr2e1-/- mice. These results indicate that Nr2e1 deletion can significantly alter both synaptic plasticity and dendritic structure in the dentate gyrus.

Links

PubMed Online version:10.1016/j.neuroscience.2005.08.091

Keywords

Animals; Dendrites/physiology; Dendrites/ultrastructure; Dentate Gyrus/cytology; Dentate Gyrus/physiology; Dentate Gyrus/ultrastructure; Electric Stimulation; Electrodes, Implanted; Electrophysiology; Female; Genotype; Histocytochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity/physiology; Receptors, Cytoplasmic and Nuclear/genetics; Receptors, Cytoplasmic and Nuclear/physiology; Reverse Transcriptase Polymerase Chain Reaction; Synapses/physiology; Synapses/ultrastructure; Synaptic Transmission/genetics; Synaptic Transmission/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:NR2E1

acts_upstream_of_or_within

GO:0048814: regulation of dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2176490

P

  • regulates_o_occurs_in:(CL:0000117)
  • regulates_o_occurs_in:(EMAPA:19037)

Seeded From UniProt

complete

MOUSE:NR2E1

acts_upstream_of_or_within

GO:0060291: long-term synaptic potentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2176490

P

Seeded From UniProt

complete


See also

References

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