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PMID:16222444

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Citation

Tian, H, Ou, J, Strom, SC and Venkataramanan, R (2005) Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. Pharm. Res. 22:2007-15

Abstract

Glucuronidation pathway is very important in the detoxification of endogenous and exogenous compounds. The objective of this study was to evaluate the activity and expression of various hepatic uridine diphosphate glucuronosyltransferases (UGTs) in rats at various time points after initiation of hepatic regeneration by partial hepatectomy (PHx).

Links

PubMed Online version:10.1007/s11095-005-8111-1

Keywords

Animals; Biological Markers; DNA Primers; Gene Expression Regulation, Enzymologic/genetics; Gene Expression Regulation, Enzymologic/physiology; Glucuronosyltransferase/biosynthesis; Glucuronosyltransferase/genetics; Glucuronosyltransferase/metabolism; Hepatectomy; Interleukin-6/metabolism; Isoenzymes/biosynthesis; Isoenzymes/metabolism; Liver/enzymology; Liver Regeneration/physiology; Male; Microsomes, Liver/enzymology; RNA/biosynthesis; RNA/isolation & purification; RNA, Messenger/biosynthesis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:UD11

involved_in

GO:0031100: animal organ regeneration

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:UD13

involved_in

GO:0031100: animal organ regeneration

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:UD12

involved_in

GO:0031100: animal organ regeneration

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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