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PMID:16191204

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Citation

Duh, FM, Dirks, C, Lerman, MI and Miller, AD (2005) Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus. Retrovirology 2:59

Abstract

Infection by jaagsiekte sheep retrovirus (JSRV) and by enzootic nasal tumor virus (ENTV) depends on cell-surface expression of the virus entry receptor, hyaluronidase 2 (Hyal2). Human Hyal2 binds the envelope (Env) proteins of these viruses and is functional as a receptor, but Hyal2 from mice does not bind Env nor does it mediate entry of either virus. Here we have explored the amino acid determinants that account for the difference in receptor function.

Links

PubMed PMC1262777 Online version:10.1186/1742-4690-2-59

Keywords

Animals; Bee Venoms/enzymology; Cell Adhesion Molecules/chemistry; Cell Adhesion Molecules/physiology; Conserved Sequence; Crystallization; GPI-Linked Proteins; Gene Products, env/chemistry; Humans; Hyaluronoglucosaminidase/chemistry; Hyaluronoglucosaminidase/physiology; Jaagsiekte sheep retrovirus/physiology; Mice; NIH 3T3 Cells; Rats; Rats, Inbred F344; Receptors, Virus/chemistry; Receptors, Virus/physiology; Structure-Activity Relationship

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:HYAL2

NOT|enables

GO:0001618: virus receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:HYAL2

involved_in

GO:0051607: defense response to virus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:HYAL2

NOT|located_in

GO:0031362: anchored component of external side of plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:HYAL2

enables

GO:0001618: virus receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:HYAL2

located_in

GO:0031362: anchored component of external side of plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:HYAL2

located_in

GO:0005783: endoplasmic reticulum

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

HUMAN:HYAL2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P31621

F

Seeded From UniProt

complete

JSRV:ENV

enables

GO:0019899: enzyme binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q12891

F

Seeded From UniProt

complete


See also

References

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