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PMID:16107853

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Citation

Sarin, KY, Cheung, P, Gilison, D, Lee, E, Tennen, RI, Wang, E, Artandi, MK, Oro, AE and Artandi, SE (2005) Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436:1048-52

Abstract

TERT, the protein component of telomerase, serves to maintain telomere function through the de novo addition of telomere repeats to chromosome ends, and is reactivated in 90% of human cancers. In normal tissues, TERT is expressed in stem cells and in progenitor cells, but its role in these compartments is not fully understood. Here we show that conditional transgenic induction of TERT in mouse skin epithelium causes a rapid transition from telogen (the resting phase of the hair follicle cycle) to anagen (the active phase), thereby facilitating robust hair growth. TERT overexpression promotes this developmental transition by causing proliferation of quiescent, multipotent stem cells in the hair follicle bulge region. This new function for TERT does not require the telomerase RNA component, which encodes the template for telomere addition, and therefore operates through a mechanism independent of its activity in synthesizing telomere repeats. These data indicate that, in addition to its established role in extending telomeres, TERT can promote proliferation of resting stem cells through a non-canonical pathway.

Links

PubMed PMC1361120 Online version:10.1038/nature03836

Keywords

Animals; Bromodeoxyuridine/metabolism; Cell Proliferation; DNA-Binding Proteins/deficiency; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Enzyme Induction; Hair Follicle/cytology; Hair Follicle/enzymology; Mice; Mice, Transgenic; RNA/genetics; Stem Cells/cytology; Stem Cells/enzymology; Telomerase/deficiency; Telomerase/genetics; Telomerase/metabolism; Transgenes/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:TERT

enables

GO:0003720: telomerase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

MOUSE:TERT

involved_in

GO:2000648: positive regulation of stem cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:1000428)

Seeded From UniProt

complete

MOUSE:TERT

involved_in

GO:0042635: positive regulation of hair cycle

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TERT

involved_in

GO:2000648: positive regulation of stem cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:1000428)

Seeded From UniProt

complete

MOUSE:TERT

enables

GO:0003720: telomerase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

part_of:(GO:0007004)

Seeded From UniProt

complete

MOUSE:TERT

involved_in

GO:0007004: telomere maintenance via telomerase

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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