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PMID:16083904
| Citation |
Möller, A, Avila, FW, Erickson, JW and Jäckle, H (2005) Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression. J. Mol. Biol. 352:329-37 |
|---|---|
| Abstract |
The SWI/SNF-like chromatin remodeling complex of Drosophila, the Brahma complex, contains four subunits (Brahma, BAP155/Moira, SNR1 and BAP60) conserved from yeast to humans. A reconstituted human complex lacking the BAP60 homolog shows full remodeling activity, suggesting that BAP60 is not essential for the core function. We generated Drosophila mutants and found that BAP60 carries a vital function and participates in complex-mediated transcriptional activation and repression. BAP60 binds DNA and shows genetic and physical interactions with the sex-determining transcription factors encoded by sisterless A and scute. The results support the conclusion that BAP60 participates in site-specific recruitment of the Brahma complex in Drosophila. |
| Links |
PubMed Online version:10.1016/j.jmb.2005.07.009 |
| Keywords |
Amino Acid Sequence; Animals; Basic-Leucine Zipper Transcription Factors; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Dosage Compensation, Genetic; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Female; Gene Expression Regulation, Developmental; Male; Molecular Sequence Data; Mutation; Protein Binding; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; Sequence Homology, Amino Acid; Sex Determination Processes; Trans-Activators/genetics; Trans-Activators/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic; Transcriptional Activation; X Chromosome/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
DROME:AST4 |
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
FB:FBgn0025463 |
F |
Seeded From UniProt |
complete | |
|
DROME:BAP60 |
enables |
GO:0008134: transcription factor binding |
ECO:0000250: sequence similarity evidence used in manual assertion |
HGNC:11106 |
F |
Seeded From UniProt |
complete | |
|
DROME:BAP60 |
involved_in |
GO:0010628: positive regulation of gene expression |
ECO:0000316: genetic interaction evidence used in manual assertion |
FB:FBgn0000212 |
P |
Seeded From UniProt |
complete | |
|
DROME:BAP60 |
involved_in |
GO:0031453: positive regulation of heterochromatin assembly |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:BAP60 |
enables |
GO:0003677: DNA binding |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
DROME:BAP60 |
enables |
GO:0001085: RNA polymerase II transcription factor binding |
ECO:0000353: physical interaction evidence used in manual assertion |
FB:FBgn0004170 |
F |
Seeded From UniProt |
complete | |
|
DROME:BAP60 |
enables |
GO:0001085: RNA polymerase II transcription factor binding |
ECO:0000353: physical interaction evidence used in manual assertion |
FB:FBgn0003411 |
F |
Seeded From UniProt |
complete | |
|
DROME:SISA |
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
FB:FBgn0025463 |
F |
Seeded From UniProt |
complete | |
See also
References
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