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PMID:15978588

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Citation

Sánchez-Nogueiro, J, Marín-García, P and Miras-Portugal, MT (2005) Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice. FEBS Lett. 579:3783-8

Abstract

The presence of ionotropic P2X(7) receptor has been studied in mice brain from wild type and P2X(7) receptor knockout animals. Western blot and immunocytochemical assays show the presence of a protein containing the P2X(7) immunogenic epitopes in the brain of knockout model. Reverse transcriptase polymerase chain reaction experiments demonstrate the absence of the disrupted sequence, but other sequences of P2X(7) specific mRNA expression have been detected. Functional calcium imaging experiments in cultured granule neurons from P2X(7) knockout cerebella show the existence of a functional P2X(7)-like receptor that keeps some of the properties of the genuine receptor.

Links

PubMed Online version:10.1016/j.febslet.2005.05.073

Keywords

Animals; Cerebellum/cytology; Mice; Mice, Knockout; Neurons/chemistry; Neurons/immunology; Neurons/metabolism; RNA, Messenger/analysis; RNA, Messenger/metabolism; Receptors, Purinergic P2/analysis; Receptors, Purinergic P2/genetics; Receptors, Purinergic P2/metabolism; Receptors, Purinergic P2X7

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:P2RX7

acts_upstream_of_or_within

GO:0033198: response to ATP

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2386080

P

  • occurs_in:(CL:0000120)
  • occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:P2RX7

acts_upstream_of_or_within

GO:0010043: response to zinc ion

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2386080

P

  • occurs_in:(CL:0000120)
  • occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:P2RX7

located_in

GO:0043025: neuronal cell body

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000120)
  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:P2RX7

acts_upstream_of_or_within

GO:0051592: response to calcium ion

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2386080

P

  • occurs_in:(CL:0000120)
  • occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

See also

References

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