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PMID:15876356

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Citation

Sagane, K, Hayakawa, K, Kai, J, Hirohashi, T, Takahashi, E, Miyamoto, N, Ino, M, Oki, T, Yamazaki, K and Nagasu, T (2005) Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice. BMC Neurosci 6:33

Abstract

ADAM22 is a member of the ADAM gene family, but the fact that it is expressed only in the nervous systems makes it unique. ADAM22's sequence similarity to other ADAMs suggests it to be an integrin binder and thus to have a role in cell-cell or cell-matrix interactions. To elucidate the physiological functions of ADAM22, we employed gene targeting to generate ADAM22 knockout mice.

Links

PubMed PMC1142324 Online version:10.1186/1471-2202-6-33

Keywords

ADAM Proteins/deficiency; ADAM Proteins/genetics; ADAM Proteins/physiology; Animals; Ataxia/genetics; Ataxia/metabolism; Ataxia/pathology; Cells, Cultured; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers, Myelinated/metabolism; Nerve Fibers, Myelinated/pathology; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Peripheral Nerves/metabolism; Peripheral Nerves/pathology; Peripheral Nervous System Diseases/genetics; Peripheral Nervous System Diseases/metabolism; Peripheral Nervous System Diseases/pathology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:ADA22

acts_upstream_of_or_within

GO:0022011: myelination in peripheral nervous system

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3584137

P

  • occurs_in:(EMAPA:18577)

Seeded From UniProt

complete

MOUSE:ADA22

acts_upstream_of_or_within

GO:0008344: adult locomotory behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3584137

P

Seeded From UniProt

complete

MOUSE:ADA22

acts_upstream_of_or_within

GO:0014037: Schwann cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3584137

P

Seeded From UniProt

complete


See also

References

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