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PMID:15712282

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Citation

Ayyub, C, Sen, A, Gonsalves, F, Badrinath, K, Bhandari, P, Shashidhara, LS, Krishna, S and Rodrigues, V (2005) Cullin-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development. Dev. Dyn. 232:865-75

Abstract

We describe a developmental analysis of Drosophila Cullin-5 (Cul-5) identified from the genome sequence on the basis of its high degree of homology to vertebrate and worm sequences. The gene is expressed in a restricted manner in ectodermal cells throughout development suggesting pleiotropic functions. We decided to examine the phenotypes of Cul-5 aberrations in two well-studied developmental systems: the neuromuscular junction (NMJ) and the developing sensory organ. Alteration of Cul-5 levels in motoneurons results in an increase in bouton number at the NMJ. The cells of a sensory organ on the adult notum arise from a single progenitor cell by regulated cell division. Aberrations in Cul-5 affect different steps in the lineage consistent with a role in cell fate determination, proliferation, and death. Such phenotypes highlight the multiple cellular processes in which Cul-5 can participate.

Links

PubMed Online version:10.1002/dvdy.20322

Keywords

Amino Acid Sequence; Animals; Cell Division; Cullin Proteins/chemistry; Cullin Proteins/genetics; Cullin Proteins/metabolism; Cullin Proteins/ultrastructure; Drosophila/embryology; Drosophila/genetics; Drosophila/growth & development; Drosophila/ultrastructure; Drosophila Proteins/chemistry; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/ultrastructure; Embryo, Nonmammalian; Gene Expression; Gene Expression Regulation; Genes, Insect; Larva; Metamorphosis, Biological; Molecular Sequence Data; Mutation; Neuromuscular Junction/cytology; Neuromuscular Junction/embryology; Neuromuscular Junction/ultrastructure; Neurons, Afferent/cytology; Neurons, Afferent/ultrastructure; Organogenesis; Pupa; RNA, Messenger/metabolism; Sequence Homology, Amino Acid; Synapses/metabolism; Synapses/ultrastructure

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q8SYJ7

involved_in

GO:0016360: sensory organ precursor cell fate determination

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8SYJ7

involved_in

GO:0007528: neuromuscular junction development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VAQ0

involved_in

GO:0016360: sensory organ precursor cell fate determination

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VAQ0

involved_in

GO:0007528: neuromuscular junction development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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