GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:15705806

From GONUTS
Jump to: navigation, search
Citation

Revankar, CM, Cimino, DF, Sklar, LA, Arterburn, JB and Prossnitz, ER (2005) A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307:1625-30

Abstract

The steroid hormone estrogen regulates many functionally unrelated processes in numerous tissues. Although it is traditionally thought to control transcriptional activation through the classical nuclear estrogen receptors, it also initiates many rapid nongenomic signaling events. We found that of all G protein-coupled receptors characterized to date, GPR30 is uniquely localized to the endoplasmic reticulum, where it specifically binds estrogen and fluorescent estrogen derivatives. Activating GPR30 by estrogen resulted in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology.

Links

PubMed Online version:10.1126/science.1106943

Keywords

Animals; Antisense Elements (Genetics); Calcium/metabolism; Cell Line; Cell Line, Tumor; Cell Membrane/metabolism; Cell Nucleus/metabolism; Endoplasmic Reticulum/metabolism; Estradiol/metabolism; Estrogen Receptor alpha/metabolism; Estrogens/metabolism; Humans; Nuclear Envelope/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphatidylinositol Phosphates/metabolism; Protein Transport; Receptor, Epidermal Growth Factor/metabolism; Receptors, Estrogen/metabolism; Receptors, G-Protein-Coupled/metabolism; Recombinant Fusion Proteins/metabolism; Signal Transduction; Transfection

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:ESR1

enables

GO:0005496: steroid binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

RAT:ESR1

involved_in

GO:0030518: intracellular steroid hormone receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ESR1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:ESR1

involved_in

GO:0007204: positive regulation of cytosolic calcium ion concentration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ESR1

involved_in

GO:0007200: phospholipase C-activating G protein-coupled receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ESR1

involved_in

GO:0010863: positive regulation of phospholipase C activity

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ESR1

involved_in

GO:0071392: cellular response to estradiol stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ESR2

enables

GO:0005496: steroid binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:GPER1

enables

GO:0005496: steroid binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:GPER1

involved_in

GO:0030518: intracellular steroid hormone receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER1

located_in

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:GPER1

involved_in

GO:0032962: positive regulation of inositol trisphosphate biosynthetic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER1

involved_in

GO:0014068: positive regulation of phosphatidylinositol 3-kinase signaling

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER1

NOT|located_in

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:GPER1

located_in

GO:0005794: Golgi apparatus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:GPER1

located_in

GO:0005635: nuclear envelope

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:GPER1

enables

GO:0030284: estrogen receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:GPER1

involved_in

GO:0051281: positive regulation of release of sequestered calcium ion into cytosol

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER1

involved_in

GO:0045742: positive regulation of epidermal growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER1

involved_in

GO:0071392: cellular response to estradiol stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER

involved_in

GO:0071392: cellular response to estradiol stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER

involved_in

GO:0032962: positive regulation of inositol trisphosphate biosynthetic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER

involved_in

GO:0030518: intracellular steroid hormone receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER

enables

GO:0030284: estrogen receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:GPER

involved_in

GO:0014068: positive regulation of phosphatidylinositol 3-kinase signaling

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER

NOT|part_of

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:GPER

part_of

GO:0005794: Golgi apparatus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:GPER

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:GPER

part_of

GO:0005635: nuclear envelope

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:GPER

involved_in

GO:0051281: positive regulation of release of sequestered calcium ion into cytosol

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER

involved_in

GO:0045742: positive regulation of epidermal growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GPER

enables

GO:0005496: steroid binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.