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PMID:15673568

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Citation

Murali, D, Yoshikawa, S, Corrigan, RR, Plas, DJ, Crair, MC, Oliver, G, Lyons, KM, Mishina, Y and Furuta, Y (2005) Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development 132:913-23

Abstract

The Bmp family of secreted signaling molecules is implicated in multiple aspects of embryonic development. However, the cell-type-specific requirements for this signaling pathway are often obscure in the context of complex embryonic tissue interactions. To define the cell-autonomous requirements for Bmp signaling, we have used a Cre-loxP strategy to delete Bmp receptor function specifically within the developing mouse retina. Disruption of a Bmp type I receptor gene, Bmpr1a, leads to no detectable eye abnormality. Further reduction of Bmp receptor activity by removing one functional copy of another Bmp type I receptor gene, Bmpr1b, in the retina-specific Bmpr1a mutant background, results in abnormal retinal dorsoventral patterning. Double mutants completely lacking both of these genes exhibit severe eye defects characterized by reduced growth of embryonic retina and failure of retinal neurogenesis. These studies provide direct genetic evidence that Bmpr1a and Bmpr1b play redundant roles during retinal development, and that different threshold levels of Bmp signaling regulate distinct developmental programs such as patterning, growth and differentiation of the retina.

Links

PubMed Online version:10.1242/dev.01673

Keywords

Animals; Body Patterning; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins/metabolism; Cell Proliferation; Chromosome Mapping; Fibroblast Growth Factors/metabolism; Gene Expression Regulation, Developmental; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Transgenic; Models, Biological; Models, Genetic; Mutation; Neurons/metabolism; Optic Nerve/embryology; Protein-Serine-Threonine Kinases/biosynthesis; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/physiology; Receptors, Growth Factor/biosynthesis; Receptors, Growth Factor/genetics; Receptors, Growth Factor/physiology; Retina/embryology; Retina/metabolism; Signal Transduction; Transgenes

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:BMR1A

acts_upstream_of_or_within

GO:0009953: dorsal/ventral pattern formation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:107191

P

  • occurs_in:(EMAPA:17168)

Seeded From UniProt

complete

MOUSE:BMR1B

acts_upstream_of_or_within

GO:0009953: dorsal/ventral pattern formation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1338938

P

  • occurs_in:(EMAPA:17168)

Seeded From UniProt

complete

MOUSE:BMR1B

acts_upstream_of_or_within

GO:0043010: camera-type eye development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1338938

P

  • results_in_development_of:(EMAPA:17168)

Seeded From UniProt

complete

See also

References

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