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PMID:15618964

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Citation

Li, ZY, Liu, DP and Liang, CC (2005) New insight into the molecular mechanisms of MLL-associated leukemia. Leukemia 19:183-90

Abstract

Rearrangements of the MLL gene (ALL1, HRX, and Hrtx) located at chromosome band 11q23 are commonly involved in adult and pediatric cases of primary acute leukemias and also found in cases of therapy-related secondary leukemias. Studies on mouse models of MLL translocation and cell lines containing MLL rearrangements showed that the MLL gene linked chromosomal rearrangements to cellular differentiation and tumor tropism. Moreover, recent structural/functional studies on MLL and aberrant MLL proteins provided new clues and suggested that different mechanisms might be included in leukemogenesis by MLL rearrangements. The connection between these different mechanisms will help us understand globally how aberrant MLL oncogenes affect the normal cellular processes at molecular level.

Links

PubMed Online version:10.1038/sj.leu.2403602

Keywords

DNA-Binding Proteins/genetics; Gene Rearrangement; Humans; Leukemia/genetics; Mutation; Myeloid-Lymphoid Leukemia Protein; Proto-Oncogenes/genetics; Transcription Factors/genetics; Zinc Fingers/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:KMT2A

involved_in

GO:0035162: embryonic hemopoiesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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