PMID:15580626

Citation	Takahashi, M and Osumi, N (2005) Identification of a novel type II classical cadherin: rat cadherin19 is expressed in the cranial ganglia and Schwann cell precursors during development. Dev. Dyn. 232:200-8
Abstract	To identify a novel type II classical cadherin, we searched the genome database and found rat cadherin19 (cad19) with high similarity to human cadherin19. We also found nucleotide sequences corresponding to rat cad19 in mouse and chicken genomes. In situ hybridization of rat cad19 revealed that rat cad19 mRNA was initially expressed in cephalic neural crest cells, and then in the cranial ganglia, migrating trunk neural crest cells, the nascent dorsal root ganglia, and the sympathetic ganglia. Expression of cad19 overlapped with that of neural crest markers, including Sox10 and AP-2, but cad19 expression was confined to subpopulations of the neural crest-derived cells, those typically observed in the satellite glia at the periphery of the ganglia and Schwann cell precursors along the peripheral nerves. cad19 mRNA was not detected in cells expressing Phox2b, an epibranchial placode-derived neurons, nor in those expressing neuronal markers such as Hu protein. These observations suggest that cad19 is expressed in neural crest-derived, non-neuronal cells. Although the expression of cad19 mRNA persisted in Schwann cell precursors at E14.5, it was no longer detected in maturing Schwann cells at later stages. These results suggest that cad19 is an evolutionarily conserved cadherin and may be involved in the early development of Schwann cells in the peripheral nervous system.
Links	PubMed Online version:10.1002/dvdy.20209
Keywords	Amino Acid Sequence; Animals; Brain/embryology; Cadherins/biosynthesis; Cadherins/genetics; DNA-Binding Proteins/metabolism; Databases as Topic; Evolution, Molecular; Ganglia/embryology; Gene Expression Regulation; Gene Expression Regulation, Developmental; High Mobility Group Proteins/metabolism; Humans; Immunohistochemistry; In Situ Hybridization; Mice; Molecular Sequence Data; Neural Crest/metabolism; Neurons/metabolism; Phylogeny; RNA, Messenger/metabolism; Rats; SOXE Transcription Factors; Schwann Cells/metabolism; Sequence Homology, Amino Acid; Time Factors; Tissue Distribution; Transcription Factor AP-2; Transcription Factors/metabolism
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