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PMID:15498789

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Citation

Ma, J, Zhou, J, Fan, S, Wang, L, Li, X, Yan, Q, Zhou, M, Liu, H, Zhang, Q, Zhou, H, Gan, K, Li, Z, Peng, C, Xiong, W, Tan, C, Shen, S, Yang, J, Li, J and Li, G (2005) Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. Carcinogenesis 26:281-91

Abstract

The epidermal growth factor (EGF)-like domain is involved in receptor-ligand interactions, extracellular matrix formation, cell adhesion and chemotaxis. Nasopharyngeal carcinoma associated gene 6 (NGX6) is a novel EGF-like domain-containing gene located at the high frequent loss of heterozygosity (LOH) region 9p21-22 associated with nasopharyngeal carcinoma (NPC). It is down-regulated in NPC and its over-expression can delay the cell cycle G(0)-G(1) progression in NPC cells. In the present study, in situ hybridization analysis, using NPC tissue microarrays, showed that loss of NGX6 expression was associated with NPC lymph node metastasis. The Tet-on gene expression system and cDNA array techniques were used to profile the potential targets of NGX6. We found that NGX6 can influence the expression of some cell adhesion molecules in NPC cells. NGX6 can associate with ezrin, a linkage between the cell membrane and cytoskeleton. The NGX6 protein was expressed on the cell surface as a glycoprotein. Ectopic induction of NGX6 can impair NPC cell migration and invasive ability as well as improve cell adhesion and gap junctional intercellular communication, and can suppress tumor formation in vivo. The data revealed that NGX6 plays a role in cell adhesion modulation in NPC cells.

Links

PubMed Online version:10.1093/carcin/bgh312

Keywords

Animals; COS Cells; Carcinoma/metabolism; Carcinoma/pathology; Cell Adhesion/physiology; Cell Adhesion Molecules/metabolism; Cell Cycle/physiology; Cell Membrane/metabolism; Cell Movement/physiology; Cercopithecus aethiops; Cytoskeletal Proteins; Cytoskeleton/metabolism; Epidermal Growth Factor/metabolism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic/physiology; Humans; Membrane Proteins/metabolism; Nasopharyngeal Neoplasms/metabolism; Nasopharyngeal Neoplasms/pathology; Phosphoproteins/metabolism; Tumor Cells, Cultured; Tumor Suppressor Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:TMM8B

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P15311

F

Seeded From UniProt

complete

HUMAN:TMM8B

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:TMM8B

involved_in

GO:0007346: regulation of mitotic cell cycle

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TMM8B

involved_in

GO:0007160: cell-matrix adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TMM8B

located_in

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:EZRI

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:A6NDV4

F

Seeded From UniProt

complete

HUMAN:BGAL

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P15311

F

Seeded From UniProt

complete

HUMAN:EZRI

enables

GO:0050839: cell adhesion molecule binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P16278

F

Seeded From UniProt

complete


See also

References

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