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PMID:15488148

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Citation

Rawlings, JS, Rennebeck, G, Harrison, SM, Xi, R and Harrison, DA (2004) Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities. BMC Cell Biol. 5:38

Abstract

The Janus kinase (JAK) cascade is an essential and well-conserved pathway required to transduce signals for a variety of ligands in both vertebrates and invertebrates. While activation of the pathway is essential to many processes, mutations from mammals and Drosophila demonstrate that regulation is also critical. The SOCS (Suppressor Of Cytokine Signaling) proteins in mammals are regulators of the JAK pathway that participate in a negative feedback loop, as they are transcriptionally activated by JAK signaling. Examination of one Drosophila SOCS homologue, Socs36E, demonstrated that its expression is responsive to JAK pathway activity and it is capable of downregulating JAK signaling, similar to the well characterized mammalian SOCS.

Links

PubMed PMC526380 Online version:10.1186/1471-2121-5-38

Keywords

Animals; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Drosophila melanogaster/enzymology; Drosophila melanogaster/genetics; Female; Gene Expression Regulation, Developmental/genetics; Gene Expression Regulation, Developmental/physiology; Genome; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/physiology; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Molecular Sequence Data; Oogenesis/genetics; Ovary/chemistry; Ovary/enzymology; Ovary/metabolism; Protein Kinases/physiology; Protein-Tyrosine Kinases/metabolism; Protein-Tyrosine Kinases/physiology; Proto-Oncogene Proteins/physiology; Receptor, Epidermal Growth Factor/physiology; Receptors, Invertebrate Peptide/physiology; Repressor Proteins/genetics; Repressor Proteins/physiology; Signal Transduction/physiology; Suppressor of Cytokine Signaling Proteins; Up-Regulation/physiology; Wing/embryology; Wing/enzymology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q7JVF1

involved_in

GO:0046426: negative regulation of receptor signaling pathway via JAK-STAT

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0004864

P

Seeded From UniProt

complete

DROME:Q7JVF1

involved_in

GO:0045742: positive regulation of epidermal growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0004569

P

Seeded From UniProt

complete

DROME:Q7JVF1

involved_in

GO:0045742: positive regulation of epidermal growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0003731

P

Seeded From UniProt

complete

DROME:Q7JVF1

involved_in

GO:0045742: positive regulation of epidermal growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0001965

P

Seeded From UniProt

complete

DROME:Q7JVF1

involved_in

GO:0045742: positive regulation of epidermal growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0003205

P

Seeded From UniProt

complete

DROME:Q8INY1

involved_in

GO:0046426: negative regulation of receptor signaling pathway via JAK-STAT

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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