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PMID:15372036

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Citation

Gliki, G, Ebnet, K, Aurrand-Lions, M, Imhof, BA and Adams, RH (2004) Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Nature 431:320-4

Abstract

During spermatogenesis in the mammalian testis, stem cells (spermatogonia) differentiate into spermatocytes, which subsequently undergo two consecutive meiotic divisions to give rise to haploid spermatids. These cells are initially round but progressively elongate, condense their nuclei, acquire flagellar and acrosomal structures, and shed a significant amount of their cytoplasm to form spermatozoa (the sperm cells) in a developmental cascade termed spermiogenesis. Defects in these processes will lead to a lack of mature sperm cells (azoospermia), which is a major cause of male infertility in the human population. Here we report that a cell-surface protein of the immunoglobulin superfamily, junctional adhesion molecule-C (JAM-C), is critically required for the differentiation of round spermatids into spermatozoa in mice. We found that Jam-C is essential for the polarization of round spermatids, a function that we attribute to its role in the assembly of a cell polarity complex.

Links

PubMed Online version:10.1038/nature02877

Keywords

Animals; Cell Adhesion Molecules/deficiency; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/metabolism; Cell Differentiation; Cell Polarity; Gene Deletion; Male; Mice; Mice, Knockout; Spermatids/cytology; Spermatids/metabolism; Spermatogenesis; cdc42 GTP-Binding Protein/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:JAM3

acts_upstream_of_or_within

GO:0007286: spermatid development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3055281

P

  • occurs_in:(CL:0000018)
  • occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:JAM3

acts_upstream_of_or_within

GO:0007283: spermatogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3055281

P

  • occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:JAM3

located_in

GO:0005911: cell-cell junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000018)
  • part_of:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:JAM3

acts_upstream_of_or_within

GO:0090138: regulation of actin cytoskeleton organization by cell-cell adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3055281

P

  • regulates_o_occurs_in:(CL:0000018)
  • regulates_o_occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:JAM2

located_in

GO:0070160: tight junction

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:JAM2

involved_in

GO:0007286: spermatid development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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