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PMID:15369677

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Citation

Inoue, T, Oz, HS, Wiland, D, Gharib, S, Deshpande, R, Hill, RJ, Katz, WS and Sternberg, PW (2004) C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling. Cell 118:795-806

Abstract

Wnt proteins are intercellular signals that regulate various aspects of animal development. In Caenorhabditis elegans, mutations in lin-17, a Frizzled-class Wnt receptor, and in lin-18 affect cell fate patterning in the P7.p vulval lineage. We found that lin-18 encodes a member of the Ryk/Derailed family of tyrosine kinase-related receptors, recently found to function as Wnt receptors. Members of this family have nonactive kinase domains. The LIN-18 kinase domain is dispensable for LIN-18 function, while the Wnt binding WIF domain is required. We also found that Wnt proteins LIN-44, MOM-2, and CWN-2 redundantly regulate P7.p patterning. Genetic interactions indicate that LIN-17 and LIN-18 function independently of each other in parallel pathways, and different ligands display different receptor specificities. Thus, two independent Wnt signaling pathways, one employing a Ryk receptor and the other a Frizzled receptor, function in parallel to regulate cell fate patterning in the C. elegans vulva.

Links

PubMed Online version:10.1016/j.cell.2004.09.001

Keywords

Amino Acid Sequence/genetics; Animals; Base Sequence/genetics; Binding Sites/physiology; Body Patterning/genetics; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/isolation & purification; Caenorhabditis elegans Proteins/metabolism; Cell Differentiation/genetics; DNA, Complementary/analysis; DNA, Complementary/genetics; Female; Frizzled Receptors; Gene Expression Regulation, Developmental/genetics; Glycoproteins/metabolism; Molecular Sequence Data; Protein Binding/physiology; Protein Structure, Tertiary/genetics; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Receptor Protein-Tyrosine Kinases/genetics; Receptor Protein-Tyrosine Kinases/isolation & purification; Receptor Protein-Tyrosine Kinases/metabolism; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/metabolism; Receptors, Neurotransmitter/genetics; Receptors, Neurotransmitter/metabolism; Signal Transduction/genetics; Wnt Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:RYK

located_in

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:WNT2

involved_in

GO:0010084: specification of animal organ axis polarity

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00003029
WB:WBGene00003395

P

Seeded From UniProt

complete

CAEEL:WNT2

involved_in

GO:0010084: specification of animal organ axis polarity

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00003029

P

Seeded From UniProt

complete

CAEEL:WNT2

involved_in

GO:0060573: cell fate specification involved in pattern specification

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00003029
WB:WBGene00003395

P

Seeded From UniProt

complete

CAEEL:WNT2

involved_in

GO:0060573: cell fate specification involved in pattern specification

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00003029

P

Seeded From UniProt

complete

CAEEL:WNT2

involved_in

GO:0040025: vulval development

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00003029
WB:WBGene00003395

P

Seeded From UniProt

complete

CAEEL:WNT2

involved_in

GO:0040025: vulval development

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00003029

P

Seeded From UniProt

complete


See also

References

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