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PMID:15353803

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Citation

Wu, P, Jiang, TX, Suksaweang, S, Widelitz, RB and Chuong, CM (2004) Molecular shaping of the beak. Science 305:1465-6

Abstract

Beak shape is a classic example of evolutionary diversification. Beak development in chicken and duck was used to examine morphological variations among avian species. There is only one proliferative zone in the frontonasal mass of chickens, but two in ducks. These growth zones are associated with bone morphogenetic protein 4 (BMP4) activity. By "tinkering" with BMP4 in beak prominences, the shapes of the chicken beak can be modulated.

Links

PubMed Online version:10.1126/science.1098109

Keywords

Animals; Beak/embryology; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins/genetics; Bone Morphogenetic Proteins/metabolism; Carrier Proteins; Cell Division; Chick Embryo; Chickens/genetics; Chickens/metabolism; Ducks/embryology; Ducks/genetics; Ducks/metabolism; Gene Transfer Techniques; Genetic Vectors; Mesoderm/metabolism; Morphogenesis; Proteins/genetics; Proteins/physiology; RNA, Messenger/genetics; RNA, Messenger/metabolism; Recombinant Proteins/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ANAPL:A5HMF8

involved_in

GO:0071730: beak formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ANAPL:A5HMF8

involved_in

GO:0071729: beak morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ANAPL:A5HMF9

involved_in

GO:0071730: beak formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:BMP4

involved_in

GO:0071730: beak formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:BMP4

involved_in

GO:0008283: cell population proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:BMP4

involved_in

GO:0048704: embryonic skeletal system morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:BMP4

involved_in

GO:0071729: beak morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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