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PMID:15245880

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Citation

Braszko, JJ (2004) Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV. Peptides 25:1195-203

Abstract

An important role for angiotensin IV (Ang IV) in the processes of learning and memory has now been well established. We have previously found that intracerebroventricular (ICV) administration of Ang IV as well as des-Phe6-Ang IV enhances learning of conditioned avoidance responses (CARs), facilitates recall of a passive avoidance (PA) task, and improves object recognition (OR) in rats. Since the dopaminergic system is crucial for the cognitive processes, in this study our aim was to determine the dopaminergic D1 mediation of these effects using SCH 23390 as a selective D1 receptor antagonist. Male Wistar rats (180-200 g), pretreated with SCH 23390 (R-[+]-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine) 0.05 mg/kg intraperitoneally (IP), were given Ang IV or des-Phe6-Ang IV (1 nmol ICV) 1 h later and then tested in the above cognitive paradigms, as well as in the open field and an elevated 'plus' maze to control for the unspecific, respectively, motor and emotional, effects of our treatments. Both, Ang IV and des-Phe6-Ang IV effectively enhanced learning of CARs (P < 0.05), recall of PA (P < 0.001), and improved OR (P < 0.001). Pretreatment with SCH 23390 abolished the cognitive effects of both peptides. SCH 23390, Ang IV, and des-Phe6-Ang IV, given at the same doses and routes as in the cognitive tests, did not significantly influence crossings, rearings and bar approaches in the open field, nor the parameters measured in the elevated 'plus' maze, thus making a major contribution of the unspecific effects of our treatments to the results of the memory tests improbable. In conclusion, these results indicate that the functional dopaminergic D1 receptors are necessary for the Ang IV and des-Phe6-Ang IV cognitive effects to occur.

Links

PubMed Online version:10.1016/j.peptides.2004.04.014

Keywords

Angiotensin II/analogs & derivatives; Angiotensin II/pharmacology; Animals; Avoidance Learning/drug effects; Benzazepines/pharmacology; Brain/drug effects; Brain/physiology; Cognition/drug effects; Cognition/physiology; Exploratory Behavior/drug effects; Male; Maze Learning/drug effects; Motor Activity/drug effects; Rats; Rats, Wistar; Receptors, Dopamine D1/metabolism; Recognition (Psychology)/drug effects

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:ANGT

involved_in

GO:0008306: associative learning

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ANGT

involved_in

GO:0035106: operant conditioning

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:DRD1

involved_in

GO:0035106: operant conditioning

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:DRD1

involved_in

GO:0008306: associative learning

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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