PMID:15192231

Citation	Lee, H, Habas, R and Abate-Shen, C (2004) MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis. Science 304:1675-8
Abstract	During embryogenesis, differentiation of skeletal muscle is regulated by transcription factors that include members of the Msx homeoprotein family. By investigating Msx1 function in repression of myogenic gene expression, we identified a physical interaction between Msx1 and H1b, a specific isoform of mouse histone H1. We found that Msx1 and H1b bind to a key regulatory element of MyoD, a central regulator of skeletal muscle differentiation, where they induce repressed chromatin. Moreover, Msx1 and H1b cooperate to inhibit muscle differentiation in cell culture and in Xenopus animal caps. Our findings define a previously unknown function for "linker" histones in gene-specific transcriptional regulation.
Links	PubMed Online version:10.1126/science.1098096
Keywords	Animals; Cell Differentiation; Cell Line; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/metabolism; Enhancer Elements, Genetic; Gene Expression Regulation, Developmental; Histones/genetics; Histones/metabolism; Homeodomain Proteins/chemistry; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; MSX1 Transcription Factor; Mice; Models, Genetic; Muscle Development; Muscle, Skeletal/cytology; Muscle, Skeletal/metabolism; Mutation; MyoD Protein/genetics; Myoblasts/cytology; Myoblasts/metabolism; Precipitin Tests; Protein Binding; RNA Interference; Recombinant Proteins/metabolism; Regulatory Sequences, Nucleic Acid; Transcription Factors/chemistry; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic; Xenopus/embryology; Xenopus/metabolism; Xenopus Proteins
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