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PMID:15170700

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Citation

Tsai, YC and Sun, YH (2004) Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development. Genesis 39:141-53

Abstract

unpaired (upd) encodes a ligand for the Jak/STAT signaling pathway in Drosophila. In the second instar and early third larval eye disc, upd is expressed in the center of the posterior margin. upd loss-of-function mutations caused eye size reduction and upd overexpression caused eye enlargement. Upd regulates eye size through the Dome/Jak(Hop)/STAT92 signaling pathway to promote cell proliferation. Interestingly, the effect of Upd is only on cells located anterior to the morphogenetic furrow (MF), but has no effect on the second mitotic wave, which is posterior to MF. Overexpression of upd behind MF can nonautonomously induce cell proliferation up to 20 rows of cells anterior to MF. The G1 cyclin, cycD transcript level was also enhanced anterior to MF. Consistent with the long-range effect, we found that the extracellular Upd protein can be detected over a comparable long range, suggesting that Upd acts directly over a long distance as a signaling molecule.

Links

PubMed Online version:10.1002/gene.20035

Keywords

Animals; Cell Cycle; Cell Proliferation; Cyclin D; Cyclin G; Cyclins/genetics; Cyclins/metabolism; DNA-Binding Proteins/physiology; Drosophila Proteins/physiology; Drosophila melanogaster/embryology; Drosophila melanogaster/metabolism; Eye/embryology; Gene Expression Regulation, Developmental; Janus Kinase 1; Ligands; Mitosis; Morphogenesis; Mutation; Protein-Tyrosine Kinases/physiology; STAT Transcription Factors; Signal Transduction; Trans-Activators/physiology; Transcription Factors/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:O96525

involved_in

GO:0001745: compound eye morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:JAK

involved_in

GO:0001745: compound eye morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8MZC7

involved_in

GO:0001745: compound eye morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DOME

involved_in

GO:0001745: compound eye morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VWW4

involved_in

GO:0001745: compound eye morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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