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PMID:15118123

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Citation

Fremeau, RT Jr, Kam, K, Qureshi, T, Johnson, J, Copenhagen, DR, Storm-Mathisen, J, Chaudhry, FA, Nicoll, RA and Edwards, RH (2004) Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science 304:1815-9

Abstract

Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal.

Links

PubMed Online version:10.1126/science.1097468

Keywords

Animals; Animals, Newborn; Brain/cytology; Brain/metabolism; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Membrane/physiology; Cells, Cultured; Cerebellum/metabolism; Cerebellum/ultrastructure; Excitatory Postsynaptic Potentials; Glutamic Acid/metabolism; Hippocampus/cytology; Hippocampus/metabolism; Hippocampus/ultrastructure; In Situ Hybridization; Membrane Transport Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins/metabolism; Neurons/metabolism; Neurons/physiology; Patch-Clamp Techniques; Purkinje Cells/physiology; Pyramidal Cells/metabolism; Synapses/metabolism; Synapses/ultrastructure; Synaptic Transmission; Synaptic Vesicles/metabolism; Synaptic Vesicles/physiology; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2; Vesicular Transport Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:VGLU1

located_in

GO:0045202: synapse

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000679)
  • part_of:(EMAPA:32845)

Seeded From UniProt

complete

MOUSE:VGLU1

acts_upstream_of_or_within

GO:0051938: L-glutamate import

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3617803

P

  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

MOUSE:VGLU1

acts_upstream_of_or_within

GO:0060079: excitatory postsynaptic potential

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3617803

P

  • occurs_in:(CL:0000117)
  • occurs_in:(EMAPA:32845)

Seeded From UniProt

complete

MOUSE:VGLU1

acts_upstream_of_or_within

GO:0035249: synaptic transmission, glutamatergic

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3617803

P

  • occurs_in:(EMAPA:32768)|occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:VGLU1

involved_in

GO:0098700: neurotransmitter loading into synaptic vesicle

ECO:0001225: knockout evidence used in manual assertion

P

  • occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

MOUSE:VGLU1

involved_in

GO:0098700: neurotransmitter loading into synaptic vesicle

ECO:0006042: cell fractionation evidence used in manual assertion

P

  • occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

MOUSE:VGLU1

part_of

GO:0045202: synapse

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32845)
  • part_of:(CL:0000679)

Seeded From UniProt

complete

MOUSE:VGLU1

acts_upstream_of_or_within

GO:0051938: L-glutamate import

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3617803

P

occurs_in:(CL:0000117)

Seeded From UniProt

complete

MOUSE:VGLU1

acts_upstream_of_or_within

GO:0035249: synaptic transmission, glutamatergic

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3617803

P

occurs_in:(EMAPA:32768)|occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:VGLU1

involved_in

GO:0098700: neurotransmitter loading into synaptic vesicle

ECO:0001225: knockout evidence used in manual assertion

P

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

MOUSE:VGLU1

involved_in

GO:0098700: neurotransmitter loading into synaptic vesicle

ECO:0006042: cell fractionation evidence used in manual assertion

P

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

MOUSE:VGLU1

acts_upstream_of_or_within

GO:0060079: excitatory postsynaptic potential

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3617803

P

  • occurs_in:(EMAPA:32845)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete


See also

References

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