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PMID:15051637

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Citation

Williams, ML, Hata, JA, Schroder, J, Rampersaud, E, Petrofski, J, Jakoi, A, Milano, CA and Koch, WJ (2004) Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. Circulation 109:1590-3

Abstract

Failing human myocardium is characterized by an attenuated contractile response to beta-adrenergic receptor (betaAR) stimulation due to changes in this signaling cascade, including increased expression and activity of the beta-adrenergic receptor kinase (betaARK1). This leads to desensitization and downregulation of betaARs. Previously, expression of a peptide inhibitor of betaARK1 (betaARKct) has proven beneficial in several animal models of heart failure (HF).

Links

PubMed Online version:10.1161/01.CIR.0000125521.40985.28

Keywords

Adenoviridae/genetics; Adenylate Cyclase/metabolism; Adrenergic beta-Agonists/pharmacology; Carrier Proteins/genetics; Carrier Proteins/pharmacology; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Gene Therapy; Genes, Reporter; Genetic Vectors/genetics; Genetic Vectors/pharmacology; Green Fluorescent Proteins; Heart Failure/enzymology; Heart Failure/pathology; Heart Ventricles/pathology; Humans; Isoproterenol/pharmacology; Luminescent Proteins/analysis; Luminescent Proteins/genetics; Myocardial Contraction/drug effects; Myocytes, Cardiac/enzymology; Peptides; Recombinant Proteins; Transduction, Genetic; beta-Adrenergic Receptor Kinases

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ARBK1

involved_in

GO:0003108: negative regulation of the force of heart contraction by chemical signal

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ARBK1

involved_in

GO:0045988: negative regulation of striated muscle contraction

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ARBK1

involved_in

GO:0060048: cardiac muscle contraction

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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