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PMID:14726550

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Citation

Gum, ET, Swanson, RA, Alano, C, Liu, J, Hong, S, Weinstein, PR and Panter, SS (2004) Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death. Stroke 35:590-5

Abstract

Studies using animal models of stroke have shown that human serum albumin (HSA) significantly ameliorates cerebral ischemic injury after both transient and permanent ischemia, even when administered after the onset of ischemia or reperfusion. The mechanism of this effect remains uncertain, and prior studies suggest both indirect hemodynamic and direct cytoprotective effects. HSA is a potent antioxidant, in part because of its strong copper-binding capacity. Here we examined the effect of HSA on oxidant-induced neuronal death in a cortical cell culture system.

Links

PubMed Online version:10.1161/01.STR.0000110790.05859.DA

Keywords

Animals; Ascorbic Acid/metabolism; Astrocytes/cytology; Cell Death/drug effects; Cell Survival/drug effects; Cells, Cultured; Coculture Techniques; Copper/metabolism; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists/toxicity; Humans; Hydrogen Peroxide/antagonists & inhibitors; Hydrogen Peroxide/toxicity; Mice; N-Methylaspartate/toxicity; Neurons/cytology; Neurons/drug effects; Neurons/metabolism; Oligopeptides/pharmacology; Oxidants/antagonists & inhibitors; Oxidants/metabolism; Oxidants/toxicity; Oxidative Stress/drug effects; Serum Albumin/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ALBU

involved_in

GO:0043069: negative regulation of programmed cell death

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ALBU

enables

GO:0016209: antioxidant activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

HUMAN:ALBU

enables

GO:0005507: copper ion binding

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete


See also

References

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